Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral …

AP South, NY den Breems, T Richa, U Nwagu… - Scientific reports, 2019 - nature.com
… We identify that mutations linked to DNA adducts associated with tobacco smoke exposure
are … growth and increased susceptibility to mutations from tobacco carcinogen DNA adducts. …

Diet-related DNA adduct formation in relation to carcinogenesis

LY Hemeryck, L Vanhaecke - Nutrition reviews, 2016 - academic.oup.com
… Alcohol or ethanol consumption is a proven cause of cancer and has long been linked to
the occurrence of hepatocellular carcinomas and squamous-cell carcinomas of the oral cavity, …

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans

B Hwa Yun, J Guo, M Bellamri… - Mass spectrometry …, 2020 - Wiley Online Library
… It is now possible to measure some DNA adducts in human … formation and biological effects
of DNA adducts, and highlight our advances … for carcinogen DNA adduct biomarker research. …

DNA Adducts as Biomarkers To Predict, Prevent, and Diagnose Disease—Application of Analytical Chemistry to Clinical Investigations

C Hernandez-Castillo, J Termini… - Chemical Research in …, 2019 - ACS Publications
… , formation, and metabolism of DNA adducts has been one of … analytical methods to
measure DNA adducts, define their … cell carcinoma (ESCC) and head and neck squamous cell

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
… We then applied this method to the analysis of HPB-releasing DNA adducts in oral cells
cell carcinoma (HNSCC) patients and 35 cancer-free controls. HPB-releasing DNA adducts

Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors

I Ohnishi, Y Iwashita, Y Matsushita, S Ohtsuka… - Genes and …, 2021 - Springer
… for these carcinogenic and irreversible mutations involve DNA adduct formation, which is the
… to DNA and form DNA adducts. Certain DNA adducts may impede accurate DNA replication …

Toxicology of DNA adducts formed upon human exposure to carcinogens: Insights gained from molecular modeling

KA Wilson, RW Kung, SD Wetmore - Advances in Molecular Toxicology, 2016 - Elsevier
… The present contribution highlights the critical role of computer modeling in the DNA adduct
DNA adducts will be provided. Subsequently, the structural information obtained from DNA

Tobacco-specific carcinogens induce hypermethylation, DNA adducts, and DNA damage in bladder cancer

F Jin, J Thaiparambil, SR Donepudi, V Vantaku… - Cancer Prevention …, 2017 - AACR
… in levels of methylated metabolites, DNA adducts, and extensive DNA damage in bladder
cancer cells. Cotreatment of bladder cancer cells with these carcinogens and the methylation …

DNA adducts from anticancer drugs as candidate predictive markers for precision medicine

A Stornetta, M Zimmermann, GD Cimino… - Chemical research in …, 2017 - ACS Publications
DNA modification and biological response are addressed. A positive correlation between
DNA adduct … the high potential of using DNA adducts from anticancer drugs as mechanism-…

Spatial mapping of the DNA adducts in cancer

KL Krieger, EK Mann, KJ Lee, E Bolterstein… - DNA repair, 2023 - Elsevier
… in DNA adduct detection and quantification methods, there is an opportunity to identify DNA
adducts … However, most DNA adduct detection methods require isolation or separation of the …