Analysis of O6-[4-(3-Pyridyl)-4-oxobut-1-yl]-2′-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N′-Nitrosonornicotine
J Yang, PW Villalta, P Upadhyaya… - Chemical research in …, 2016 - ACS Publications
… Levels of this adduct as well as the other POB-DNA adducts were evaluated with respect
to our hypothesis that metabolites of (R)-NNN could enhance DNA adduct levels caused by (S)-…
to our hypothesis that metabolites of (R)-NNN could enhance DNA adduct levels caused by (S)-…
[HTML][HTML] What causes human cancer? Approaches from the chemistry of DNA damage
H Kasai - Genes and Environment, 2016 - Springer
… of oxidative DNA damage in a human population. 2) Lipid peroxide-derived DNA adducts: …
Some of these adducts were detected in human DNA. These mutagens may be involved in …
Some of these adducts were detected in human DNA. These mutagens may be involved in …
DNA damage checkpoint response to aflatoxin B1
… Thus, AFB1 putatively results in carcinogenic development by inducing the formation of
DNA adducts and genetic alterations in targeted liver cells. The reactive intermediate of AFB1, …
DNA adducts and genetic alterations in targeted liver cells. The reactive intermediate of AFB1, …
Genotoxicity of quinone: an insight on DNA adducts and its LC-MS-based detection
… However, the low content of DNA adducts and the large number of unknown DNA adducts
… quinone-induced DNA adducts and the strategies for detecting DNA adducts based on liquid …
… quinone-induced DNA adducts and the strategies for detecting DNA adducts based on liquid …
Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A
A Stornetta, KCK Deng, S Danielli… - Biochemical …, 2018 - Elsevier
… We assessed DNA adduct formation and intracellular concentrations of PR-104H and PR-104M,
and also quantified the DNA damage response to crosslinks (formation of phospho-…
and also quantified the DNA damage response to crosslinks (formation of phospho-…
[HTML][HTML] The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo [a] pyrene: effects in Trp53 (+/+), Trp53 (+/–) and Trp53 …
AM Krais, EN Speksnijder, JPM Melis, R Indra… - Archives of …, 2016 - Springer
… To evaluate the impact of the cellular Trp53 status on the metabolic activation of … DNA
adduct formation of BaP and 3-NBA in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice. DNA adduct …
adduct formation of BaP and 3-NBA in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice. DNA adduct …
Estrogen-DNA Adducts and Breast Cancer Risk in Premenopausal Asian Women
CH Lin, M Zahid, WH Kuo, FC Hu, MY Wang… - Cancer Prevention …, 2023 - AACR
… the natural log of the estrogen-DNA adduct ratio in premenopausal women was a significant
… with the estrogen-DNA adduct ratios. In conclusion, plasma estrogen-DNA adduct ratio was …
… with the estrogen-DNA adduct ratios. In conclusion, plasma estrogen-DNA adduct ratio was …
Simultaneous analysis of six aldehyde-DNA adducts in salivary DNA of nonsmokers and smokers using stable isotope dilution liquid chromatography electrospray …
X Li, L Liu, H Wang, J Chen, B Zhu, H Chen… - … of Chromatography B, 2017 - Elsevier
… six aldehyde-DNA adducts and to assess potential DNA damage induced by aldehydes, …
aldehyde-DNA adducts of these four aldehydes are listed in Table 1. DNA adducts play an …
aldehyde-DNA adducts of these four aldehydes are listed in Table 1. DNA adducts play an …
Aflatoxin-Guanine DNA Adducts and Oxidatively Induced DNA Damage in Aflatoxin-Treated Mice in Vivo as Measured by Liquid Chromatography-Tandem Mass …
… In this context, it should be emphasized that there are many factors that can affect the
operational measurement of molecules such as DNA adducts. All DNA adducts measured in this …
operational measurement of molecules such as DNA adducts. All DNA adducts measured in this …
Cigarette smoking, BPDE-DNA adducts, and aberrant promoter methylations of tumor suppressor genes (TSGs) in NSCLC from Chinese population
Y Jin, P Xu, X Liu, C Zhang, C Tan, C Chen… - Cancer …, 2016 - Taylor & Francis
… smoking and BPDE-DNA adducts with promoter methylations … (MSP), and BPDE-DNA adduct
level in lung cancer tissue was … histology type was sequamous cell carcinoma (SCC, 52%) …
level in lung cancer tissue was … histology type was sequamous cell carcinoma (SCC, 52%) …