… cells ultimately need to be producing high-affinity antibodies. Low-affinity interactions are
sufficient to induce initial B-cell … These low-affinity B cells may develop without reentering B-cell …

… affinity antibody responses. This can be attributed to the complexity of B cell differentiation
and affinity … , which makes these highly specialized cells susceptible to rapid apoptosis ex vivo…

… B-cell to plasma cell differentiation during the germinal center reaction has been shown. To
investigate if antigen affinity-based Tfh cell … model that integrates cellular interactions with a …

… of TCR affinity on differentiation and T cell/DC … T cells with differing TCR affinities for the
same p:MHCII ligand (20). We found that Th cells with low-, medium-, or high-affinity TCR T cells …

… of the cell product. For most applications, the requisite purity is only achievable through affinity
… for developing cell-targeting affinity ligands and their application in cell purification, along …

… the affinity of the T cell antigen receptor for self antigen drives the differentiation of T reg cells
into … are distinct; this is expected if TCR specificity is linked to T reg cell differentiation. The …

… Nevertheless, the process whereby GC B cells differentiate into PCs is … PC differentiation
of only high-affinity GC B cells remains unknown. In this study, we show that differentiation into …

… ), our lab previously showed that Blimp1 + PCs specifically differentiate from high-affinity
but not low-affinity B cell precursors within the GC [15]. Given the relationship between BCR …

… subset [19 •• ] (Figure 1b–e), demonstrated that half of the clones generated only one
type of cellular subset, indicating that antigen affinity influences fate choice. In addition, the …

… B cells differ in their affinity for antigen throughout … cell receptor affinity for antigen is one of
the important determinants in the cell fate decision for plasma cell and GC B cell differentiation…