… This article appraises the key literature on the contemporary management of non-small cell
lung cancer patients with acquired resistance to EGFR TKIs, and envisions future directions …

… and focus on the major cause of mortality for lung cancer patients: acquired resistance. We
… acquired resistance, as it remains the major scientific and clinical challenge in lung cancer. …

… understanding of primary and acquired resistance mechanisms in NSCLC. In the first part,
resistance mechanisms of 6 FDA-approved ICIs-related primary resistance are collected and …

… in classification of acquired resistance that require urgent … in lung cancer suggest unique
underlying determinants of durable clinical benefit and resistance in non-small-cell lung cancer (…

… About 5% of patients suffered from transformation from EGFR-mutant adenocarcinoma to
small-cell lung cancer (SCLC) after acquired resistance to EGFR TKIs [35]. A possible theory is …

… acquired resistance is based on temporal and objectively measurable criteria, it is likely that
what we call “acquired resistance… the “intrinsic resistance”) and new resistance mechanisms …

… acquired resistance to them, which presents another challenge in the treatment of NSCLC.
The mechanisms of acquired resistance … to overcome the acquired resistance to EGFR TKI. …

… to clarify the mechanisms underlying acquired resistance and how to overcome them. Here
… -cell lung cancer (SCLC) was cytologically documented, probably upon acquired resistance …

… However, no role has been reported for AURKB in the context of resistance … tumor cells
with acquired resistance to EGFR TKIs and can be a therapeutic target in absence of resistance …

… mechanisms, we defined the sensitivity of a panel of KRAS G12C–mutant lung cancer cell
… we created two cell lines that acquired resistance to AMG510 and the underlying resistance …