… -cell signaling network profiling … network characterization using single-cell data and
discuss potential confounding factors that need to be considered in single-cell signaling network …

… the activity of cell signaling pathways is currently much more difficult. eXpression2Kinases
(X2K) computationally predicts involvement of upstream cell signaling pathways, given a …

… is the “cancer stem-cell (SC) model” … cells, the cancer-initiating cells (CICs) or cancer stem
cells (CSCs), as they will be referred to in this article [1]. This model implies a hierarchy of cells …

… the dynamics of signaling networks and how this information can be extracted experimentally.
We start by considering undirected protein interaction networks derived from proteomic …

… networks of interacting cells. Given their centrality in cellular decision-making, cell-to-cell
signaling networks play … For example, cell-to-cell signaling is known to coordinate responses to …

… For demonstration, we explore the network topology of cell–cell signaling based on
Vascular Endothelial Growth Factor A (Vegfa) over time. Figure 4B–D suggests that there is a …

… a comprehensive understanding of signaling network function are daunting. The … cellular
signaling network need to be identified and their temporal response to different levels of cellular …

… problem as one where the T cell signaling network must discriminate between two inputs:
infected APCs that present a small number of agonist ligands (a bona fide signal) in a sea of …

… Cells … signaling networks that relay extracellular cues into the cell, culminating in the
reprogramming of various biochemical, genetic, and structural processes. The cellular signaling …

… K-RAS is central in cellular signaling network of pancreatic cancer cells. … As K-RAS mutations
control a wide array of cell signaling pathways (Fig. 2), it was expected that these mutations …