Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR

N Zhu, C Zhang, A Prakash, Z Hou, W Liu… - EMBO molecular …, 2021 - embopress.org
… host cell signaling network comprised of S1P 2 , EGFR, and CysLT1. GBS exploitation of such
network … and knockdown cells, and gene knockout animals, as well as interrogation of the …

Protein self-assembly: a new frontier in cell signaling

S Saad, DF Jarosz - Current opinion in cell biology, 2021 - Elsevier
… diverse roles that protein disorder plays in biology, multiple properties of prion self-assembly
provide appealing advantages in the context of signal processing and cellular ‘memory.’ …

Extracting intercellular signaling network of cancer tissues using ligand-receptor expression patterns from whole-tumor and single-cell transcriptomes

JX Zhou, R Taramelli, E Pedrini, T Knijnenburg… - Scientific Reports, 2017 - nature.com
… Given the wide functional variety of cells among tumor cells of the same clone (intraclonal
or … intra-tumor cell-cell signaling consists of heterotypic interactions between cells of distinct …

Surface sensing and signaling networks in plant pathogenic fungi

Y Kou, NI Naqvi - Seminars in Cell & Developmental Biology, 2016 - Elsevier
… require intricate coordination in cell signaling and differentiation in phytopathogenic fungi.
Here, we present an overview of our current understanding of cell signaling and infection-…

Information-theoretic analysis of multivariate single-cell signaling responses

T Jetka, K Nienałtowski, T Winarski… - PLoS computational …, 2019 - journals.plos.org
… The above questions resulted in a considerable interest to study cellular signaling within
the framework of information theory. Unfortunately, the utilization of the information-theoretic …

Cell signaling pathways that promote radioresistance of cancer cells

MM Ouellette, S Zhou, Y Yan - Diagnostics, 2022 - mdpi.com
… (IR) can activate numerous cellular signaling pathways which lead to the induction of
senescence, apoptosis, autophagy (leading to cell death or survival), and/or cell cycle checkpoint …

SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks

L Csabai, D Fazekas, T Kadlecsik… - Nucleic acids …, 2022 - academic.oup.com
networks we made a leading step in signaling network research. However, with the
emergence of single-cell … a way to create cell-type specific networks with further developments. …

Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

I Jantan, MA Haque, L Arshad, H Harikrishnan… - The Journal of nutritional …, 2021 - Elsevier
… inflammation-associated cell signaling networks are deliberated. … inflammation-associated
cell signaling pathways, namely … various components of the networks. The suppressive effects …

High-content imaging platform for profiling intracellular signaling network activity in living cells

D Kuchenov, V Laketa, F Stein, F Salopiata… - Cell chemical …, 2016 - cell.com
… Essential characteristics of cellular signaling networks include a complex interconnected
architecture and temporal dynamics of protein activity. The latter can be monitored by Förster …

Initiation of T cell signaling by CD45 segregation at'close contacts'

VT Chang, RA Fernandes, KA Ganzinger, SF Lee… - Nature …, 2016 - nature.com
… the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how
such segregation occurs and whether it can initiate signaling is unclear. Using structural and …