… We discovered that pathway reactivation in RAS mutant models occurs at the level of CRAF
… clear pathway reactivation, we next examined effects of combining MEK and ERK inhibition. …

… evade MEK inhibition, and this often involves a re-wiring of the MAPK pathway to reactivate
… by which they can promote cell signaling, and reactivation of RTKs following MEK inhibition …

… gavage daily suppressed MAPK pathway more effectively and … alone, combined BRAF V600E
and MEK inhibitor treatment … corresponding to sustained MAPK pathway inhibition. Results …

… These include reactivation of the MAPK pathway resulting in … of the FAK pathway, both
alone and in combination with MEK … of resistance to BRAF/MEK inhibition (www.clinicaltrials.gov; …

… pathway reactivation in a large panel (n = 34) of KRAS-mutant cell lines, by measuring the
reduction of phospho-MEK … We also found that combining SHP2 and MEK inhibitors led to …

… However, incomplete pathway suppression or pathway reactivation is a major issue …
combined RAF and MEK inhibitors, as MEK inhibition can suppress the resultant ERK reactivation. …

… in part through reactivation of MAPK pathway. Intriguingly, … redundantly reactivate RAS–MAPK
and combined upstream … FGFR inhibition combined with downstream blockade of MEK …

… We show that no combination of feedbacks coming from the pathway … Combining two RAF
inhibitors blocks ERK pathway reactivation more effectively than combining RAF and MEK …

… Second, the cotargeting of MEK and resistance pathways by combining MEKi with partner
… In summary, the reactivation of the PI3K-AKT-mTOR pathway and its complex crosstalk with …

… on the BRAF/MEK/ERK pathway.Combined BRAF inhibitor (BRAFi) and MEK inhibitor (MEKi) …
ERK pathway reactivation has also been observed in melanoma mouse models12 and …