… The 22RV1 prostate cancer cell line possesses activation of the MEK/ERK pathway [23], …
on the AKT pathway [24]. We demonstrate that combination blockade of the AKT and MEK does …

… for the evaluation of upfront combination MEK and RET TKI … , upfront combination ALK/MEK
or EGFR/MEK inhibition has … inhibition via reactivation of the RAS/MAPK pathway via the …

… resistance mechanisms to BRAF and MEK inhibition. In this … Dabrafenib in combination with
trametinib versus dabrafenib … kinase blocked the pathway reactivation induced by the ligand …

… MEKi–evoked ERK MAPK pathway reactivation. A and B, … combined MEK/SHP2 inhibition
blocks cell proliferation and promotes shrinkage of tumors with increased RAS/ERK pathway …

… MEK proteins with overexpressed BRAF, which consequently initiates reactivation of the
MAPK pathway [… and ERK reactivation by feedback mechanisms, the combination of αC-IN-RAF …

… Therapeutic strategies that combine MEK inhibitors with agents that target apoptotic pathways
may be a promising therapeutic approach. We investigated combining MEK and MDM2 …

… exist to reactivate the cell proliferation and survival pathways. In particular, reactivation of …
), we hypothesized that combination therapy with a small molecule capable of inducing …

… of combining RAF-MEK1/2-ERK1/2 pathway … pathway, providing an integrated and
simplified visualization, to reveal the potentials of RAS-RAF-MEK1/2-ERK1/2-based combination …

… of a combination therapy of the MEK inhibitor trametinib … identified an alternative MAPK
pathway–activating mutation … to show that the combination of BRAF and MEK inhibition led to a …

… a rational combination approach that inhibits inhibitor-induced pathway reactivation and can
… We hypothesized that RTK reactivation in response to short-term and long-term exposure to …