… resulting in MEK-ERK pathway reactivation. … pathway reactivation, we reasoned that
PLX8394 may be a more effective BRAF inhibitor in BRAF mutant CRC for use in combination …

… The discovery of the role of the RAS/RAF/MEK/ERK pathway … The combination therapy with
MEK inhibitors is an excellent … due to the paradoxical reactivation of the MAPK pathway. The …

… in combination with either BRAF inhibitor dabrafenib or vemurafenib against BRAF V600E
cancer cell lines (119). The tolerance to this combination in … induce pathway reactivation and …

… the AREG–EGFR–MEK–STAT3 pathway to overcome therapeutic resistance associated
with RAS pathway reactivation in PDAC. In addition, combined MEKi and STAT3i inhibits CSCs …

… a combined experimental- and statistical modeling–based approach to identify a set of
pathway reactivation … to examine the nature of combination Mek and JNK inhibition on viability (…

… activity of MEK and further impair its reactivation by CRAF by … to combine MEK and PI3K
pathway inhibitors in the clinic only to be met with significant toxicity issues. Combination of MEK …

… that can reactivate ERK and other survival-related pathways. … reactivation of MEK by RAF
in vemurafenib-resistant cells (see below), initiated new strategy of combining RAF and MEK …

… MEK in HNSCC, as MEK/ERK reactivation inevitably occurs. We assessed the effects of
combining … ERK 1/2-pathway reactivation during acquired resistance has led to the identification …

… pathway hyperactivation in tumors, 7 in some instances, these drugs have demonstrated
therapeutic benefit alone or in combination … and in sensitivity to MEK pathway inhibitors (ie, MV), …

… , we propose the combination of a MEK inhibitor and a Pi3′-… due to reactivation of the ERK
signaling pathway via various … (Pi3′-kinase) pathways by inhibiting the mutated enzymes …