… Iron acquisition is essential for the proliferation of microorganisms, and human pathogens …
Cryptococcus neoformans must use sophisticated uptake mechanisms to overcome host iron …

… We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes … iron-related
phenotypes similar to those of a cir1Δ mutant, including poor growth upon iron deprivation…

… Cryptococcus neoformans is another opportunistic pathogen that causes chronic pulmonary
infections and cryptococcosis, … under iron deprivation or in media with hemin as the sole iron …

… Cryptococcus neoformans is a fungal pathogen that lives in the soil and on plants in the
environment and which infects humans through inhalation. The lungs are the primary site of …

… , Cryptococcus neoformans, and found that LYS4 expression is regulated by iron levels and
by the iron-… Therefore, we believe that iron deprivation might signal the down-regulation of …

… Pathogens must compete with hosts to acquire sufficient iron for proliferation during
pathogenesis. The pathogenic fungus Cryptococcus neoformans is capable of acquiring iron from …

… iron-related virulence factors have the most common fungal human pathogens (Aspergillus
fumigatus, Cryptococcus neoformans… synergistic effect with iron deprivation in slowing growth …

… that governing iron transport upon iron deprivation is a key role of the protein in C. … role
in regulating the response to iron deprivation compared to iron sufficiency. The ChIP-Seq and …

… host immune response and influencing phagocytosis, and capsule elaboration is regulated
by a number of host-related conditions including iron deprivation 7, 8. Effective therapy for …

… human fungal pathogen Cryptococcus neoformans within the vertebrate host, and iron
sensing … In addition, upon iron deprivation, the CBC represses the expression of the GATA-type …