Cytochrome P450 expression and regulation in the brain

W Kuban, WA Daniel - Drug Metabolism Reviews, 2021 - Taylor & Francis
liver, which also exhibits the highest expression and concentration of transmembrane cytochrome
P450 … Total CYP protein content in the brain is significantly lower compared to the liver

The regulation of liver cytochrome P450 expression and activity by the brain serotonergic system in different experimental models

E Bromek, WA Daniel - Expert Opinion on Drug Metabolism & …, 2021 - Taylor & Francis
Cytochrome P450 (CYP) enzymes are members of the … The expression of liver cytochrome
P450 is under the … -pituitary-liver axis (HPL) affecting growth hormone level/action in the …

Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes

HF Zhang, HH Wang, N Gao, JY Wei, X Tian… - … of Pharmacology and …, 2016 - ASPET
… In conclusion, we first offered the physiologic data of 10 P450 isoform contents and found …
P450 expression in human normal livers. The effects of gene polymorphisms on intrinsic P450

Expression of cytochrome P450 isozyme transcripts and activities in human livers

J Liu, YF Lu, JC Corton, CD Klaassen - Xenobiotica, 2021 - Taylor & Francis
… intact liverliver samples to profile the constitutive expression of CYP1A2, 2B6, 2C8, 2C9,
2C19, 2D6, 2E1, 3A4, and 4A11 enzyme activity and transcript levels. The mRNA expression of …

Hepatic cytochrome P450 activity, abundance, and expression throughout human development

NC Sadler, P Nandhikonda, BJ Webb-Robertson… - Drug Metabolism and …, 2016 - ASPET
… Herein, we have sought to expand our knowledge of P450 expression and activity in the
human liver from early gestation to late adulthood using classic techniques to measure gene …

[PDF][PDF] The role of human cytochrome P450 2E1 in liver inflammation and fibrosis

J Xu, HY Ma, S Liang, M Sun, G Karin… - Hepatology …, 2017 - Wiley Online Library
… Here, we analyzed mice expressing only the human CYP2E1 gene (hCYP2E1) to … function
with different liver injuries. After intragastric alcohol feeding, CYP2E1 expression was induced …

Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues

JF Robinson, EG Hamilton, J Lam, H Chen… - Placenta, 2020 - Elsevier
… To evaluate global transcriptomic differences in CYP expression between adult liver and
fetal liver and/or placenta, we searched two public databases, National Center for …

Sexual dimorphism in the expression of cytochrome P450 enzymes in rat heart, liver, kidney, lung, brain, and small intestine

SH Gerges, AOS El-Kadi - Drug Metabolism and Disposition, 2023 - ASPET
… Elucidating sex-specific differences in P450 enzyme levels could help … expression levels
of different cytochrome P450 (P450) enzymes between male and female rats in the heart, liver, …

Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model

T Chiba, K Noji, S Shinozaki, S Suzuki… - Journal of Pharmacy …, 2016 - academic.oup.com
… Non-alcoholic fatty liver disease (NAFLD) is associated with impaired liver function, and …
expression of major cytochrome P450 (CYP) subtypes in the liver and whether the expression

Acetaminophen-induced liver injury alters expression and activities of cytochrome P450 enzymes in an age-dependent manner in mouse liver

Y Bao, P Wang, X Shao, J Zhu, J Xiao, J Shi… - Drug Metabolism and …, 2020 - ASPET
… In consideration of the changes of expression and activities of P450s in mouse liver during
P450 expression is in an age-dependent manner. The current study determined expression