… Treatment of these patients with oral ribavirin and subcutaneous pegylated IFN alpha-2a
demonstrated significant improvement in survival, provided that adequate monitoring and …

… cytokines are involved in a broad range of biological processes and are implicated in various
disease pathologies. The field of cytokine therapeutics … methods to develop cytokine-based …

… Interferons may be the most potent and broadly active cytokine family for stimulating cellular
responses to nucleic acids of anomalous structure or location. In response to pathogenic …

… a better understanding of cytokine biology. We then present an overview of therapeutics
arising from cytokine re-engineering, targeting and delivery, mRNA therapeutics and cell therapy…

… λ) are potent antiviral cytokines with immunomodulatory potential, we assessed their … Both
interferon alpha (IFNα) and lambda (IFNλ) protect from influenza virus infection when mice are …

… Interferon beta (IFNβ) is a cytokine that is naturally produced … It signals by binding to the
heterodimeric type I IFN receptor … of action to its therapeutic effects. Immunogenicity and its …

… promising proinflammatory and anti-inflammatory therapeutic cytokines, both used in cancer
… therapeutic index. We also mention ongoing clinical trials that utilize engineered cytokines …

… anti-CD38 IgG4 mAb with two attenuated IFN alpha-2b molecules. Ongoing phase I/II TAK-…
an increased type I IFN gene signature and circulating IFN-associated cytokine levels. This …

… The IFN-γ receptor (IFNGR) is a member of the class II cytokine receptor family and is expressed
at moderate levels on nearly every cell type, except mature erythrocytes. The receptor is …

… cytokines and their pathways can be controlled for potential therapeutic benefit, including by
cytokine … I and type II cytokines and particularly on IL-2, given the therapeutic interest in this …