Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

RD Gray, G Hardisty, KH Regan, M Smith, CT Robb… - Thorax, 2018 - thorax.bmj.com
… of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis
is described in CF although it is unclear whether this is a primary neutrophil defect or a …

Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis

J Wang, Y Wang, J Xie, Z Zhao, S Gupta… - Blood, The Journal …, 2021 - ashpublications.org
neutrophils isolated from patients with sepsis and healthy volunteers and correlated negatively
with apoptosis rates in septic neutrophils … contributes to delayed neutrophil apoptosis, we …

Human cytomegalovirus delays neutrophil apoptosis and stimulates the release of a prosurvival secretome

JM Pocock, DML Storisteanu, MB Reeves… - Frontiers in …, 2017 - frontiersin.org
… to apoptosis may contribute to the likelihood of recurrent infections (8, 9), implying that
neutrophil apoptosis … to manipulate the apoptotic machinery of the neutrophil, either delaying

Delayed neutrophil apoptosis in granulomatosis with polyangiitis: dysregulation of neutrophil gene signature and circulating apoptosis-related proteins

M Surmiak, M Hubalewska-Mazgaj… - Scandinavian Journal …, 2020 - Taylor & Francis
… In this study, we analysed neutrophil apoptosis and levels of circulating apoptosis-related
proteins in 36 GPA patients and 18 healthy controls ( Table 1 ). All GPA patients were anti-PR3 …

Neutrophil apoptosis is delayed in an equine model of colitis: Implications for the development of systemic inflammatory response syndrome

SL Anderson, B Singh - Equine veterinary journal, 2017 - Wiley Online Library
delays neutrophil apoptosis in … on neutrophil apoptosis is diminished in neutrophils isolated
after the induction of colitis. In addition, we demonstrate that neutrophil apoptosis is delayed

Delayed neutrophil apoptosis mediates intermittent hypoxia-induced progressive heart failure in pressure-overloaded rats

S Li, J Feng, S Wei, X Qian, J Cao, B Chen - Sleep and Breathing, 2016 - Springer
… In summary, our results have revealed delayed neutrophil apoptosis accompanied by
increased pro-inflammatory factors in HF rats following exposure to IH, which exacerbated …

Mild acidosis delays neutrophil apoptosis via multiple signaling pathways and acts in concert with inflammatory mediators

D El Kebir… - Journal of Leukocyte …, 2017 - academic.oup.com
… Extracellular acidosis results in additive suppression of neutrophil apoptosis by inflammatory
mediators Having shown that extracellular acidosis delays neutrophil apoptosis, we next …

Live or die: PD-L1 delays neutrophil apoptosis

J El-Benna, PMC Dang - Blood, The Journal of the American …, 2021 - ashpublications.org
… in our understanding of neutrophil biology. Notably, their work uncovers the important function
of the PD-L1–PI3K–AKT axis in delaying neutrophil apoptosis in inflammatory situations, …

The role of neutrophil death in chronic inflammation and cancer

C Brostjan, R Oehler - Cell Death Discovery, 2020 - nature.com
… can delay neutrophil apoptosis to exploit their pro-angiogenic and pro-metastatic properties.
Conversely, neutrophils … are expelled DNA strands with neutrophil proteins. Components of …

Enhanced lactate accumulation upregulates PD‐L1 expression to delay neutrophil apoptosis in sepsis

M Fei, H Zhang, F Meng, G An, J Tang, J Tong, L Xiong… - View, 2024 - Wiley Online Library
neutrophils. Further, we explored the close relationship between lactate and delayed neutrophil
apoptosis in human neutrophils… in human neutrophils decreased neutrophil apoptosis (P …