[HTML][HTML] Naturally Inspired Molecules for Neuropathic Pain Inhibition—Effect of Mirogabalin and Cebranopadol on Mechanical and Thermal Nociceptive Threshold in …

K Sałat, P Zaręba, M Awtoniuk, R Sałat - Molecules, 2023 - mdpi.com
… 1), a naturally derived opioid drug originally isolated from … -opioid receptor (MOR), κ-opioid
receptor (KOR) and δ-opioid … [17], the results obtained in the present study confirmed the …

Antiallodynic effects of endomorphin-1 and endomorphin-2 in the spared nerve injury model of neuropathic pain in mice

C Wang, D Yang, B Yuan, T Qiu - Anesthesia & Analgesia, 2017 - journals.lww.com
… in the SNI model of neuropathic pain in mice. Also, the specific opioid receptor antagonists
were used to determine the opioid mechanisms of EMs involved in neuropathic pain. …

[HTML][HTML] Serotonin plays a key role in the development of opioid-induced hyperalgesia in mice

M Sasaki, Y Kamiya, K Bamba, T Onishi, K Matsuda… - The Journal of …, 2021 - Elsevier
… Our study offers new therapeutic targets for OIH and may help reduce inappropriate opioid
… in all images was obtained and the average of all images was calculated for each mouse. …

[HTML][HTML] Peripheral mu-opioid receptor activation by dermorphin [D-Arg2, Lys4](1–4) amide alleviates behavioral and neurobiological aberrations in rat model of …

A Gadepalli, O Ummadisetty, D Chouhan, KE Yadav… - …, 2024 - Elsevier
… Findings from the current study suggests that peripheral mu-opioid receptors may offer a
potential target for the treatment of patients suffering from CINP, offering new avenues for …

The mixed kappa and delta opioid receptor agonist, MP1104, attenuates chemotherapy-induced neuropathic pain

DV Atigari, KF Paton, R Uprety, A Váradi, AF Alder… - …, 2021 - Elsevier
opioid receptor agonists targeting the KOP and delta opioid … , is a novel mixed opioid
receptor agonist with potent … therapeutic development of mixed opioid receptor agonists, …

Opioids and TRPV1 in the peripheral control of neuropathic pain–Defining a target site in the injured nerve

D Labuz, V Spahn, MÖ Celik, H Machelska - Neuropharmacology, 2016 - Elsevier
… can be mediated by opioid receptors at the injured … opioids in neuropathy. In a chronic
constriction injury (CCI) of the sciatic nerve in mice, we assessed the effects of μ-, δ- and κ-opioid

St. John's Wort potentiates anti-nociceptive effects of morphine in mice models of neuropathic pain

MD Sanna, C Ghelardini, N Galeotti - Pain Medicine, 2017 - academic.oup.com
… of SJW to relieve neuropathic pain in mice neuropathic models … of morphine analgesia to
improve opioid efficacy in the clinical … In the hot plate test, obtained data clearly demonstrated a …

[HTML][HTML] Sex differences in kappa opioid receptor agonist mediated attenuation of chemotherapy-induced neuropathic pain in mice

KF Paton, D Luo, AC La Flamme… - Frontiers in …, 2022 - frontiersin.org
… Kappa opioid receptor (KOR) agonists are a promising alternative to currently available
opioid drugs due to their low abuse potential. In the current study, we have investigated the …

[HTML][HTML] … -1 inducer and carbon monoxide–releasing molecule enhance the effects of gabapentinoids by modulating glial activation during neuropathic pain in mice

K Godai, Y Kanmura - Pain Reports, 2018 - journals.lww.com
… been obtained regarding the effects of HO-1 induction on δ-opioid agonists or … -opioid
agonists or cannabinoid-2 agonists, HO-1 induction decreases the antiallodynic effects of δ-opioid

Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats

A Gadepalli, O Ummadisetty, D Chouhan… - International …, 2023 - Elsevier
… using the equation that has been derived from the standard curve. … -opioid agonist, loperamide
did not produce any CNS toxicities commonly observed with centrally acting opioid drugs, …