[HTML][HTML] Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

A Rodriguez-Gaztelumendi, V Spahn, D Labuz… - Pain, 2018 - journals.lww.com
… ), a newly designed m-opioid receptor (MOR) agonist with a … pain, without exhibiting
typical opioid side effects. Here, we … Our results indicate that NFEPP exerts peripheral opioid

Experimental drugs for neuropathic pain

K Salat, B Gryzlo, K Kulig - Current Neuropharmacology, 2018 - ingentaconnect.com
… It has been demonstrated that β 2 adrenoceptors and δ opioid receptors … Botulinum toxin
A is a potent neurotoxin derived from the … agonist relieving neuropathic pain in mice. Neuro…

Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain

K Sałat, M Kołaczkowski, A Furgała, A Rojek… - …, 2017 - Elsevier
… Blood samples (5 μl) for the measurement of glucose concentration were obtained from the
tail vein of the mice. The animals were considered to be diabetic when their blood glucose …

Treatment with a carbon monoxide-releasing molecule (CORM-2) inhibits neuropathic pain and enhances opioid effectiveness in rats

AM Jurga, A Piotrowska, J Starnowska… - Pharmacological …, 2016 - Springer
… Therefore, our results are in agreement with those obtained … inflammatory and neuropathic
pain in mice via interaction … effects of morphine in neuropathic pain in mice; therefore, the …

[HTML][HTML] Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms

PSA Augusto, AV Braga, FF Rodrigues… - European Journal of …, 2019 - Elsevier
… So far, it has not been investigated whether metformin increases the release of opioid
peptides by immune cells, but this is a tempting hypothesis to explain the biguanide effect in the …

Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain

S Diochot, A Alloui, P Rodrigues, M Dauvois, V Friend… - Pain, 2016 - journals.lww.com
… We now show that mambalgins also have an opioid-… relieve inflammatory and neuropathic
pain in mice by intravenous or … Peptide toxins derived from animal venoms that specifically …

[HTML][HTML] Antinociceptive profile of levo-tetrahydropalmatine in acute and chronic pain mice models: role of spinal sigma-1 receptor

DW Kang, JY Moon, JG Choi, SY Kang, Y Ryu… - Scientific Reports, 2016 - nature.com
… No relation with opioid R To examine the involvement of opioid receptor on antinociceptive
effect of l-THP, we intrathecally treated a dose of naloxone (non-selective opioid receptor …

Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice

MH Yi, YU Liu, K Liu, T Chen, DB Bosco… - Brain, behavior, and …, 2021 - Elsevier
Microglia play an important role in the central sensitization and chronic pain. However, a
direct connection between microglial function and pain development in vivo remains …

[HTML][HTML] Pharmacological Modulation of the MIP-1 Family and Their Receptors Reduces Neuropathic Pain Symptoms and Influences Morphine Analgesia: Evidence …

A Ciechanowska, K Pawlik, K Ciapała, J Mika - Brain Sciences, 2023 - mdpi.com
… chemokines play essential roles in opioid analgesia. The … Importantly, we obtained similar
analgesic properties after a … in CCI-induced [16] neuropathic pain in mice. Many studies have …

Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice

G Zhang, N Liu, C Zhu, L Ma, J Yang, J Du… - International …, 2019 - Elsevier
… of isoorientin in CCI-induced neuropathic pain in mice and explore the underlying mechanisms
of … The supernatant was obtained, and the total protein content was measured with a total …