… Similar results were obtained with the co-administration of DADS (30 mg/kg) or GYY4137 (…
donors during nerve injury-induced neuropathic pain in mice. These findings indicate that the …

The efficacy of µ-opioid receptors (MOR) in neuropathic pain is low and with numerous side
effects that limited their use. Chronic neuropathic pain is also linked with emotional …

… enhance the naturally derived ligustrazine hydrochloride, in … ) in treatment of neuropathic
pain in mice with sciatic nerve … Indeed, in this study, the opioid receptor antagonist naloxone …

… We also performed recordings in lamina II to compare our observations with those
obtained in other neuropathic pain models. We observed a reduction in the frequency, but not …

… This study addresses the need to phase out opioids as the major analgesic drugs for moderate
to … The results obtained using α9 KO mice are consistent with this mechanism. Thus, this …

… The mean paw withdrawal latency of both the contralateral and ipsilateral paws was obtained
from the average of three distinct trials with a 5-min break between trials. The mice were …

… to indirectly activate the opioid system through β-endorphin release, and the blockade of
the … Mice were obtained from the animal housing unit of the Laboratory of Experimental …

… Immunofluorescence images were obtained with a fluorescence microscope (Nikon Eclipse
… All immunofluorescence data were obtained in a minimum of 5–7 serial sections from the …

… Central sensitization is associated with several presynaptic (opioid receptors, calcium
channels) and postsynaptic molecular structures (glutamate receptors, AMPA/kainate receptors, …

… However, while the analgesic potential derived from the stimulation of CB1R is accompanied
with several central site effects, the administration of selective CB2R agonists inhibited …