… Accordingly, the stage has been set for a shift to a systems-level perspective. This shift has
been catalyzed by new technology and methods in systems and chemical biology that aim to …

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling
protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are …

… chemical biology, in particular synthesis of peptides and peptidomimetics for probing
biological … to address long-standing problems in Chemical Biology. Her research efforts aim at …

… in chemical biology and drug discovery. Here we review the state of the field in the context
of harnessing chirality as a source of chemical information at the chemistry-biology interface. …

… In this review, we highlight recent studies in which chemical probes and chemical biology
approaches were utilized for the study of Mtb. These chemical probes can be classified as …

… biological receptors make carboranes exquisite frameworks in the design of probes for chemical
biology, … new design tools in medicinal chemistry and chemical biology, showcasing the …

… chemical probes, is a direct and efficient approach for establishing disease relevance.
Chemical … When applied at scale, phenotypic chemical biology advances our understanding of …

… Additionally, we highlight those CMPs for which further chemical biology efforts are required
to identify suitable enzymatic inhibitors to probe their biology and transfer them into the clinic…

… of the systems biology based approaches to drug design. Also discussed are systems biology
… of the existing resources for a systems biology based drug discovery paradigm (open TG-…

… resulting molecule would possess potential applications in medicine and chemical biology.
… Hence, we reviewed the importance of PNA in chemistry, molecular biology, drug discovery, …