… DNA demethylation in IVF embryos, we next asked if the gene expression level of Tet family
members was inhibited in IVF preimplantation embryos. … inhibited in IVF embryos at the two- …

… changes in DNA methylation can occur as a … of embryonic development. In this review, we
depict the mechanisms behind the embryonic epigenetic reprogramming of DNA methylation …

… Around embryonic day 7.5 (E7.5), primordial germ cells undergo global erasure of DNA
methylation, and new DNA methylation landscapes in male embryos are established during …

… In face of the difficulties of getting enough PGC for molecular studies, the aim of this study
was to propose an alternative method to study rat PGC DNA methylation. Rat embryos were …

… to the development of new embryos. Here, we tried to induce totipotent stem cells by … DNA
demethylation patterns of the embryo. Our data showed, after induction of DNA demethylation …

… 5mC in chicken embryos 141 and the demonstration of DNA demethylation through direct
… Later, Penn and colleagues demonstrated that 5hmC was also found in adult rats, mice and …

… , complete loss of Tet1/2/3 mRNA, and depletion of 5hmC in Tet1/2/3 f/f ;R26 +/CreER
embryos using DNA and RNA isolated from whole embryos (fig. S1, C to E). We analyzed the …

… Indeed, Verma and colleagues [41] suggested that TET proteins may protect bivalent
genes from de novo DNA methylation in human embryonic stem cells. Several other studies …

… embryos. However, smaller amounts of UHRF1 existed in the nucleus, consistent with the
expected role in DNA methylation. We … , a large proportion of the embryos derived from the KO …

… DNA methylation levels seen in mouse sperm samples [30, 31]. Rat and mouse brain global
CpG DNA methylation … average CpG DNA methylation levels of our mouse and rat blood …