The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
… somatic cell development. Finally, we provide insights into DNA methylation gained from …
insights gained into the patterning of DNA methylation during development. Finally, we discuss …

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

AE Jaffe, Y Gao, A Deep-Soboslay, R Tao… - Nature …, 2016 - nature.com
… In conclusion, the epigenetic landscape represented by DNA methylation in the human brain
varies markedly across development. Genetic loci implicated in risk for schizophrenia and …

DNA methylation reprogramming during mammalian development

Y Zeng, T Chen - Genes, 2019 - mdpi.com
… , are usually devoid of methylation [2]. DNA methylation is essential for mammalian development
and is involved in … Aberrant DNA methylation patterns and mutations of genes encoding …

Dynamic DNA methylation in plant growth and development

A Bartels, Q Han, P Nair, L Stacey, H Gaynier… - International journal of …, 2018 - mdpi.com
… that DNA methylation is dynamic during plant development. For example, DNA methylation
… Furthermore, DNA methylation levels vary in different cell types in gametophytes that have …

[HTML][HTML] DNA methylation in development and disease: an overview for prostate researchers

DB Joseph, DW Strand, CM Vezina - American journal of clinical …, 2018 - ncbi.nlm.nih.gov
… the DNA methylation machinery. More specifically, we describe DNA methylation in the context
of prostate development, … and environmental factors on DNA methylation in the prostate. …

DNA methylation homeostasis in human and mouse development

M Iurlaro, F von Meyenn, W Reik - … opinion in genetics & development, 2017 - Elsevier
The molecular pathways that regulate gain and loss of DNA methylation during mammalian
development need to be tightly balanced to maintain a physiological equilibrium. Here we …

DNA methylation and DNA methyltransferases

JR Edwards, O Yarychkivska, M Boulard… - Epigenetics & …, 2017 - Springer
… of the shape of genomic methylation patterns and the nature … development. We observe
that the sequences that undergo deep changes in methylation status during early development

[HTML][HTML] DNA methylation, environmental exposures and early embryo development

M Breton-Larrivée, E Elder, S McGraw - Animal reproduction, 2019 - SciELO Brasil
development. In this review, we depict the mechanisms behind the embryonic epigenetic
reprogramming of DNA methylation and … affect development and DNA methylation marks. …

DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes

Z Chen, F Miao, BH Braffett, JM Lachin, L Zhang… - Nature …, 2020 - nature.com
… Here, we show the involvement of epigenetic DNA methylation (DNAme) in metabolic … , and
with subsequent development of complications over an 18-yr period in the blood DNA of 499 …

Role of TET enzymes in DNA methylation, development, and cancer

KD Rasmussen, K Helin - Genes & development, 2016 - genesdev.cshlp.org
DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and
DNA methylation … ) and promote locus-specific reversal of DNA methylation. TET genes, and …