The DNA methylation landscape in cancer

K Skvortsova, C Stirzaker, P Taberlay - Essays in biochemistry, 2019 - portlandpress.com
… and advances to distinguish major and minor DNA methylation intermediates such as 5hmC
from 5mC [15,16], the field is building comprehensive maps of DNA methylation landscapes

[HTML][HTML] Navigating the DNA methylation landscape of cancer

A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation patterns are maintained by the daughter DNA through a maintenance
DNA methylation … Both de novo DNA methylation and maintenance DNA methylation are …

The DNA methylation landscape of advanced prostate cancer

SG Zhao, WS Chen, H Li, A Foye, M Zhang… - Nature …, 2020 - nature.com
DNA methylation is a key regulator of gene expression, the comprehensive methylation
landscape of … We also identified intergenic regions where methylation is associated with RNA …

DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus

Z Zhou, B Sun, X Li, C Zhu - Nutrition & metabolism, 2018 - Springer
… Epigenetics, in particular DNA methylation, was also implicated in the pathogenesis of …
This review focused on DNA methylation landscapes in such insulin-sensitive organs as …

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

J Klughammer, B Kiesel, T Roetzer, N Fortelny… - Nature medicine, 2018 - nature.com
… of DNA methylation sequencing in large cohorts of routinely collected clinical FFPE tumor
samples. To put the DNA methylation data … us to identify DNA methylation patterns predictive of …

DNA methylation landscape reflects the spatial organization of chromatin in different cells

L Zhang, WJ Xie, S Liu, L Meng, C Gu, YQ Gao - Biophysical journal, 2017 - cell.com
… the correlation of DNA methylation levels … DNA methylation landscape using published
whole-genome bisulfite sequencing (WGBS) data, which we expect to reflect the packing of DNA

Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

M Delacher, CD Imbusch, D Weichenhan… - Nature …, 2017 - nature.com
… Our analysis of the pattern of DNA methylation (the 'methylome') revealed 11,000
differentially methylated regions (DMRs) associated with about 4,000 genes. Shared epigenetic …

Impact of mutations in DNA methylation modification genes on genome-wide methylation landscapes and downstream gene activations in pan-cancer

CJ Lee, H Ahn, D Jeong, M Pak, JH Moon… - BMC medical genomics, 2020 - Springer
… As a result, we found that genome-wide methylation landscapes were significantly different
… the DNA methylation modifier genes. Second, we investigated the effect of DNA methylations …

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

DN Weinberg, S Papillon-Cavanagh, H Chen, Y Yue… - Nature, 2019 - nature.com
… clustering of published DNA methylation array profiles 21,24 … in EZH2 22 —have a DNA
methylome that is similar to that of … for understanding how DNA methylation landscapes are …

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

RN Batra, A Lifshitz, AT Vidakovic, SF Chin… - Nature …, 2021 - nature.com
… To this rich resource, we now add data on DNA methylation landscapes using reduced …
DNA methylation. The model represents 6 global trends that affect breast DNA methylation