Modeling drug passage into human milk

PO Anderson, JB Sauberan - Clinical Pharmacology & …, 2016 - Wiley Online Library
human studies can reliably quantify drug passage into breastmilk. The standard method of
quantifying drug passage into breastmilk is the administration of a drug … she is taking the drug

Non-clinical models to determine drug passage into human breast milk

D Ventrella, M Forni, ML Bacci… - Current Pharmaceutical …, 2019 - ingentaconnect.com
drug passage into human milk’, ie. assessment or prediction of (variability of) drug
concentration-time profiles in human milk … nursing infants during maternal drug therapy. In this …

[HTML][HTML] A comprehensive review on non-clinical methods to study transfer of medication into breast milk–A contribution from the ConcePTION project

N Nauwelaerts, N Deferm, A Smits, C Bernardini… - Biomedicine & …, 2021 - Elsevier
… transfer of medication into the human milk. However, reliable … in culture for at least 15 passages
and could represent a good … often applied to predict drug-drug interactions and to select …

Developing an in vitro to in vivo extrapolation (IVIVE) model to predict human milk-to-plasma drug concentration ratios

H Yang, I Xue, Q Gu, P Zou, T Zhang, Y Lu… - Molecular …, 2022 - ACS Publications
… Determining the amount of drug transferred into human milk is critical for benefit–risk analysis
… pH of human milk during lactation, we conducted a sensitivity analysis by setting milk pH at …

Drugs and chemical contaminants in human breast milk

A Anadón, MR Martínez-Larrañaga, I Ares… - Reproductive and …, 2017 - Elsevier
… serum protein may contribute to drug excretion into human milk. The nonionized fraction of
any … Because the blood–brain barrier (BBB) is not fully developed in neonates, drug passage

Selective serotonin reuptake inhibitors' passage into human milk of lactating women

L Pogliani, S Baldelli, D Cattaneo, P Pileri… - The Journal of …, 2019 - Taylor & Francis
… the passage of these drugs into human milk, often with conflicting results. Here, we sought
to evaluate the passage of selective serotonin reuptake inhibitors into human milk in the first …

Drugs in lactation

PO Anderson - Pharmaceutical research, 2018 - Springer
… The principles of drug passage into … drug does not affect the quantity and/or quality of human
milk and there is reasonable certainty either that the drug is not detectable in human milk or …

Passage of Venlafaxine in Human Milk During 12 Months of Lactation: A Case Report

S Baldelli, L Pogliani, L Schneider… - Therapeutic Drug …, 2022 - journals.lww.com
… 5 A limited amount of data, mainly single assessments at heterogeneous time points after
delivery, are available on the distribution of venlafaxine in human milk and on drug exposure …

Generic Workflow to predict medicine concentrations in human milk using Physiologically-based pharmacokinetic (PBPK) Modelling—A contribution from the …

N Nauwelaerts, J Macente, N Deferm, RH Bonan… - Pharmaceutics, 2023 - mdpi.com
… Non-clinical methods have the potential to generate quantitative data in an early (drug
Information regarding the extent and rate of passage of medicines across the blood–milk

Clinical lactation studies and the role of pharmacokinetic modeling and simulation in predicting drug exposures in breastfed infants

PO Anderson, JD Momper - Journal of pharmacokinetics and …, 2020 - Springer
… data on drug passage into breastmilk for individual drugs are often lacking and human studies
… , and usually studies have been done on drugs that have some human milk excretion data …