Modeling drug passage into human milk
PO Anderson, JB Sauberan - Clinical Pharmacology & …, 2016 - Wiley Online Library
… human studies can reliably quantify drug passage into breastmilk. The standard method of
quantifying drug passage into breastmilk is the administration of a drug … she is taking the drug …
quantifying drug passage into breastmilk is the administration of a drug … she is taking the drug …
Non-clinical models to determine drug passage into human breast milk
… drug passage into human milk’, ie. assessment or prediction of (variability of) drug
concentration-time profiles in human milk … nursing infants during maternal drug therapy. In this …
concentration-time profiles in human milk … nursing infants during maternal drug therapy. In this …
[HTML][HTML] A comprehensive review on non-clinical methods to study transfer of medication into breast milk–A contribution from the ConcePTION project
N Nauwelaerts, N Deferm, A Smits, C Bernardini… - Biomedicine & …, 2021 - Elsevier
… transfer of medication into the human milk. However, reliable … in culture for at least 15 passages
and could represent a good … often applied to predict drug-drug interactions and to select …
and could represent a good … often applied to predict drug-drug interactions and to select …
Developing an in vitro to in vivo extrapolation (IVIVE) model to predict human milk-to-plasma drug concentration ratios
… Determining the amount of drug transferred into human milk is critical for benefit–risk analysis
… pH of human milk during lactation, we conducted a sensitivity analysis by setting milk pH at …
… pH of human milk during lactation, we conducted a sensitivity analysis by setting milk pH at …
Drugs and chemical contaminants in human breast milk
A Anadón, MR Martínez-Larrañaga, I Ares… - Reproductive and …, 2017 - Elsevier
… serum protein may contribute to drug excretion into human milk. The nonionized fraction of
any … Because the blood–brain barrier (BBB) is not fully developed in neonates, drug passage …
any … Because the blood–brain barrier (BBB) is not fully developed in neonates, drug passage …
Selective serotonin reuptake inhibitors' passage into human milk of lactating women
L Pogliani, S Baldelli, D Cattaneo, P Pileri… - The Journal of …, 2019 - Taylor & Francis
… the passage of these drugs into human milk, often with conflicting results. Here, we sought
to evaluate the passage of selective serotonin reuptake inhibitors into human milk in the first …
to evaluate the passage of selective serotonin reuptake inhibitors into human milk in the first …
Drugs in lactation
PO Anderson - Pharmaceutical research, 2018 - Springer
… The principles of drug passage into … drug does not affect the quantity and/or quality of human
milk and there is reasonable certainty either that the drug is not detectable in human milk or …
milk and there is reasonable certainty either that the drug is not detectable in human milk or …
Passage of Venlafaxine in Human Milk During 12 Months of Lactation: A Case Report
S Baldelli, L Pogliani, L Schneider… - Therapeutic Drug …, 2022 - journals.lww.com
… 5 A limited amount of data, mainly single assessments at heterogeneous time points after
delivery, are available on the distribution of venlafaxine in human milk and on drug exposure …
delivery, are available on the distribution of venlafaxine in human milk and on drug exposure …
Generic Workflow to predict medicine concentrations in human milk using Physiologically-based pharmacokinetic (PBPK) Modelling—A contribution from the …
N Nauwelaerts, J Macente, N Deferm, RH Bonan… - Pharmaceutics, 2023 - mdpi.com
… Non-clinical methods have the potential to generate quantitative data in an early (drug …
Information regarding the extent and rate of passage of medicines across the blood–milk …
Information regarding the extent and rate of passage of medicines across the blood–milk …
Clinical lactation studies and the role of pharmacokinetic modeling and simulation in predicting drug exposures in breastfed infants
PO Anderson, JD Momper - Journal of pharmacokinetics and …, 2020 - Springer
… data on drug passage into breastmilk for individual drugs are often lacking and human studies
… , and usually studies have been done on drugs that have some human milk excretion data …
… , and usually studies have been done on drugs that have some human milk excretion data …
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