Comparison of the effectiveness of erlotinib, gefitinib, and afatinib for treatment of non‑small cell lung cancer in patients with common and rare EGFR gene mutations

P Krawczyk, DM Kowalski, R Ramlau… - Oncology …, 2017 - spandidos-publications.com
EGFR mutations. When undergoing EGFR‑TKI treatment, patients with rare EGFR mutations
… between particular rare EGFR mutations and EGFR-TKIs treatment outcomes is required. …

[HTML][HTML] Efficacy and safety of afatinib for EGFR-mutant non-small cell lung cancer, compared with gefitinib or erlotinib

Y Kim, SH Lee, JS Ahn, MJ Ahn… - Cancer Research and …, 2019 - synapse.koreamed.org
… In the efficacy analysis according to EGFR mutation type, the T790M … Our study confirms
the previous efficacy data of afatinib for NSCLC harboring uncommon EGFR mutations other …

FDA Approval of Gefitinib for the Treatment of Patients with Metastatic EGFR Mutation–Positive Non–Small Cell Lung Cancer

D Kazandjian, GM Blumenthal, W Yuan, K He… - Clinical Cancer …, 2016 - AACR
… of the patient population most likely to derive benefit from EGFR TKIs, and to new trials in …
that the EGFR mutation status of a patient's tumor is predictive of gefitinib efficacy in Asian …

Association of pharmacokinetics and pharmacogenomics with safety and efficacy of gefitinib in patients with EGFR mutation positive advanced non-small cell lung …

T Hirose, K Fujita, S Kusumoto, Y Oki, Y Murata… - Lung Cancer, 2016 - Elsevier
… or positive for EGFR mutation [19]. Until now, the relationship between the efficacy of
gefitinib and its pharmacokinetics and pharmacogenomics in patients with EGFR mutation-positive …

A phase III randomised controlled trial of erlotinib vs gefitinib in advanced non-small cell lung cancer with EGFR mutations

JJ Yang, Q Zhou, HH Yan, XC Zhang, HJ Chen… - British journal of …, 2017 - nature.com
… erlotinib is superior to gefitinib in efficacy. The primary end … Finally, the efficacy data for erlotinib
and gefitinib indicated … superior to gefitinib in advanced NSCLC with EGFR exon 19 or 21 …

Efficacy and safety of gefitinib as third-line treatment in NSCLC patients with activating EGFR mutations treated with first-line gefitinib followed by second-line …

Y Song, YL Wu, LJ Cao, JH Chen, ZY Ma… - American Journal of …, 2019 - journals.lww.com
… the efficacy and safety of gefitinib as a third-line re-challenge treatment for advanced NSCLC
patients with EGFR mutation. … of EGFR mutations in plasma in each visit during gefitinib re-…

[HTML][HTML] A retrospective comparison of the clinical efficacy of gefitinib, erlotinib, and afatinib in Japanese patients with non-small cell lung cancer

A Fujiwara, M Yoshida, H Fujimoto, H Nakahara… - Oncology …, 2018 - ncbi.nlm.nih.gov
… The aim of this study was to compare the effectiveness of gefitinib, erlotinib, and afatinib.
We retrospectively reviewed the records of 310 patients with the diagnosis of EGFR mutation-…

Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer

K Liu, G Jiang, A Zhang, Z Li, J Jia - BMC cancer, 2020 - Springer
… icotinib and gefitinib had similar efficacy for brain metastasis of EGFR mutated NSCLC.
Large randomized studies are suggested to further illuminate the effect of these two EGFR-TKIs …

[HTML][HTML] Comparison of effectiveness of Gefitinib, Erlotinib, and Afatinib in advanced non-small cell lung cancer patients with EGFR mutation positive in Indonesian …

N Sutandyo, A Hanafi, M Jayusman - Chinese journal of lung …, 2019 - ncbi.nlm.nih.gov
… with EGFR mutation positive. This study aims to compare the effectiveness of first line TKIs;
gefitinib, … stage NSCLC patients with EGFR mutation positive in the Indonesian population. …

[HTML][HTML] … different central nervous system efficacy among gefitinib, erlotinib and afatinib in patients with epidermal growth factor receptor mutation-positive non-small …

HA Jung, SY Woo, SH Lee, JS Ahn… - Translational Lung …, 2020 - ncbi.nlm.nih.gov
… incidence of CNS failure compared with gefitinib or erlotinib after adjusting for both EGFR
mutation type and preexisting CNS metastases (HR 0.51, 95% CI, 0.34–0.75, P=0.0007). …