The safety and efficacy of osimertinib for the treatment of EGFR T790M mutation positive non-small-cell lung cancer

X Gao, X Le, DB Costa - Expert review of anticancer therapy, 2016 - Taylor & Francis
EGFR mutations, and a trend toward improved overall survival [Citation8–Citation14]. As a
result, gefitinib, … with advanced NSCLCs with EGFR exon 19 deletions or the L858R mutation. …

Clinical outcomes of gefitinib and erlotinib in patients with NSCLC harboring uncommon EGFR mutations: A pooled analysis of 438 patients

C Wang, K Zhao, S Hu, W Dong, Y Gong, M Li, C Xie - Lung Cancer, 2022 - Elsevier
… [23], [24], [25], [26], [27], [28], [29], [30] In this study, we explored the outcomes of some
relatively frequent single uncommon EGFR mutations, and differences in efficacy and prognosis …

First-line tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer: a network meta-analysis

MS Holleman, H van Tinteren, HJM Groen… - OncoTargets and …, 2019 - Taylor & Francis
… insights into the relative efficacy and toxicity of the EGFR-TKIs. … the efficacy and toxicity of
first-line treatment with gefitinib, … EGFR-mutated (exon 19 deletion or exon 21 L858R mutation) …

Next-generation EGFR/HER tyrosine kinase inhibitors for the treatment of patients with non-small-cell lung cancer harboring EGFR mutations: a review of the …

X Wang, D Goldstein, PJ Crowe… - OncoTargets and …, 2016 - Taylor & Francis
EGFR mutations (actEGFRm) EGFR L858R and EGFR Del19 , in terms of safety, efficacy, and
… They yield promising efficacy in NSCLC patients with actEGFRm as well as EGFR T790M …

EGFR mutation-guided use of afatinib, erlotinib and gefitinib for advanced non-small-cell lung cancer in Hong Kong–A cost-effectiveness analysis

JHS You, WCS Cho, W Ming, Y Li, C Kwan, K Au… - PLoS …, 2021 - journals.plos.org
… and EGFR mutation-guided gefitinib gained lower QALYs at higher costs than the erlotinib
group. Comparing with EGFR mutation… , EGFR mutation-guided afatinib, erlotinib, gefitinib and …

[HTML][HTML] Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation

F Nurwidya, F Takahashi… - Journal of natural science …, 2016 - ncbi.nlm.nih.gov
… the clinical efficacy of gefitinib as monotherapy in … EGFR mutations.[37] Patients with Stage
IIIB or IV chemotherapy-naive NSCLC with EGFR mutation were treated with 250 mg gefitinib

Clinical impact of gastric acid suppressants use on the efficacy of gefitinib in patients with advanced adenocarcinoma of the lung harboring common egfr mutations

WC Kwok, JC Man Ho, DC Leung Lam… - Clinical Cancer …, 2020 - ingentaconnect.com
… acid-suppressing medication inhibits gefitinib absorption and … -line gefitinib for NSLC harboring
common EGFR mutation. … common sensitizing EGFR mutations who received gefitinib as …

[HTML][HTML] Fruquintinib with gefitinib as first-line therapy in patients carrying EGFR mutations with advanced non-small cell lung cancer: a single-arm, phase II study

S Lu, JY Zhou, XM Niu, JY Zhou, H Jian… - Translational Lung …, 2021 - ncbi.nlm.nih.gov
efficacy and safety of fruquintinib in combination with gefitinib, … EGFR-tyrosine kinase inhibitors
(TKIs) are the standard … patients with EGFR mutation-positive NSCLC; gefitinib, an EGFR-…

The efficacy and tolerability of combining pemetrexed-based chemotherapy with gefitinib in the first-line treatment of non-small cell lung cancer with mutated EGFR: A …

BC Wang, WX Zhang, BH Kuang, GH Lin - Plos one, 2022 - journals.plos.org
… -line treatment for NSCLC harboring EGFR mutations and suggested gefitinib plus pemetrexed-…
the efficacy and tolerability of adding pemetrexed-based chemotherapy to gefitinib as the …

Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II–IIIA (N1–N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label …

WZ Zhong, Q Wang, WM Mao, ST Xu, L Wu… - The Lancet …, 2018 - thelancet.com
… We aimed to compare the efficacy of adjuvant gefitinib versus vinorelbine plus cisplatin in …
We also did biochemical and haematological analyses and EGFR mutation testing, and we …