… It was reported that KDM5A is required to develop a metastable chromatin state that enables
drug resistance in breast cancer (39) and lung cancer treated with EGFR-TKI (40). As far as …

… an increased EGFR gene copy number, as evaluated by SISH, could be used to select
patients with EGFR wild-type lung adenocarcinoma who are likely to benefit from EGFR TKI …

… (EGFR)-mutated lung adenocarcinoma patients. Methods: We included 43 patients with
advanced EGFR T790M-positive lung adenocarcinoma … progression under previous EGFR-TKI …

… A total of 1566 patients with non-small cell lung cancer were included for copy number
gain analysis. Together with the patients from 2018, 60 patients were treated with first-line, …

… lung cancer significantly improved overall survival (OS) (hazard ratio [HR] = 0.84); in a post
hoc analysis, EGFR copy number … We present the analysis of granular EGFR FISH data from …

… of EGFR mutations in early-stage lung adenocarcinoma remain … and EGFR status of patients
with lung adenocarcinoma to … in EGFR mutation rates and subtypes between early-stage …

… there is no consensus of copy number (CN) threshold to define EGFR amplification or copy
number gain (CNG), and the effect of de novo EGFR CNG on the efficacy of EGFR-TKIs in the …

… mutant EGFR protein and EGFR gene copy number do not change with tumor progression in
patients with lung adenocarcinomas with EGFR … EGFR TKIs. These results also indicate that …

… or not otherwise specified, the patient had to be negative for both EGFR mutations and
ALK rearrangements. Lung cancer specimens with KRAS mutation were not excluded from …

… [29] found that lung adenocarcinomas with EGFR … EGFR protein expression was correlated
with higher N stage… of EGFR copy number alterations in non-small cell lung cancer. Am J …