Targeting AgRP neurons to maintain energy balance: Lessons from animal models

S Zagmutt, P Mera, MC Soler-Vázquez… - Biochemical …, 2018 - Elsevier
AgRP neurons, the undeniable demonstration of their critical role in the control of energy
balance came from the study of AgRP neuron… (DTR) specifically in AgRP neurons (AgRP DTR ), …

Appetite to learn: An allostatic role for AgRP neurons in the maintenance of energy balance

F Reed, SH Lockie, A Reichenbach, CJ Foldi… - Current Opinion in …, 2022 - Elsevier
… We discuss how the sensory detection of food or food cues influences AgRP neural … AgRP
neurons transmit a negative valence learning signal when food is not present and how AgRP-…

AgRP neurons: Regulators of feeding, energy expenditure, and behavior

JD Deem, CL Faber, GJ Morton - The FEBS journal, 2022 - Wiley Online Library
… Alongside their disparate effects on energy balance, POMC and AgRP neurons are reciprocally
regulated by circulating cues of nutritional state, including the adiposity hormones leptin …

Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons

Y Qi, NJ Lee, CK Ip, R Enriquez, R Tasan, L Zhang… - Cell Metabolism, 2023 - cell.com
… in AGRP neurons may be somewhat compensated for by increased Agrp expression under
negative energy balance. … of NPY neurons in the ARC that do not co-express Agrp and that …

[HTML][HTML] Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons–Implications for energy balance and glucose control

Z He, Y Gao, L Lieu, S Afrin, J Cao, NJ Michael… - Molecular …, 2019 - Elsevier
neurons is also essential for proper energy balance [26], [27], [28], [29]. Moreover, GLP-1
receptors in POMC neurons … arcuate POMC and NPY/AgRP neuronal activity and contribute to …

[HTML][HTML] PGC-1α expression in murine AgRP neurons regulates food intake and energy balance

JF Gill, J Delezie, G Santos, C Handschin - Molecular metabolism, 2016 - Elsevier
… of various signaling pathways in AgRP neurons and thereby sheds additional light on the
regulation of whole body energy balance by hypothalamic neurons, which are attractive targets …

Regulation of substrate utilization and adiposity by Agrp neurons

JP Cavalcanti-de-Albuquerque, J Bober… - Nature …, 2019 - nature.com
… contribution of Agrp neurons to adiposity and weight gain during obesogenic conditions,
we set out to selectively activate Agrp neurons under controlled positive energy balance. We …

POMC neuronal heterogeneity in energy balance and beyond: an integrated view

C Quarta, M Claret, LM Zeltser, KW Williams… - Nature …, 2021 - nature.com
… A second neuronal population co-expressing neuropeptide Y (… (AgRP) is instead activated
by negative energy balance. Following activation, NPY/AgRP neurons inhibit POMC neurons 5…

[HTML][HTML] Insulin controls food intake and energy balance via NPY neurons

K Loh, L Zhang, A Brandon, Q Wang, D Begg, Y Qi… - Molecular …, 2017 - Elsevier
… In light of our results, the lack of effects in AgRP neuron-specific … AgRP neurons are 100%
NPY co-expressing. However, this notion that most, if not all, ARC NPY neurons are also AgRP

Control of energy expenditure by AgRP neurons of the arcuate nucleus: neurocircuitry, signaling pathways, and angiotensin

LL Morselli, KE Claflin, H Cui, JL Grobe - Current hypertension reports, 2018 - Springer
… to energy balance [5•]. In addition to neuropeptides AgRP and NPY, AgRP neurons also
release … Mice with specific deletion of the vesicular GABA transporter (Vgat) in AgRP neurons