Targeting AgRP neurons to maintain energy balance: Lessons from animal models
S Zagmutt, P Mera, MC Soler-Vázquez… - Biochemical …, 2018 - Elsevier
… AgRP neurons, the undeniable demonstration of their critical role in the control of energy
balance came from the study of AgRP neuron… (DTR) specifically in AgRP neurons (AgRP DTR ), …
balance came from the study of AgRP neuron… (DTR) specifically in AgRP neurons (AgRP DTR ), …
Appetite to learn: An allostatic role for AgRP neurons in the maintenance of energy balance
… We discuss how the sensory detection of food or food cues influences AgRP neural … AgRP
neurons transmit a negative valence learning signal when food is not present and how AgRP-…
neurons transmit a negative valence learning signal when food is not present and how AgRP-…
AgRP neurons: Regulators of feeding, energy expenditure, and behavior
… Alongside their disparate effects on energy balance, POMC and AgRP neurons are reciprocally
regulated by circulating cues of nutritional state, including the adiposity hormones leptin …
regulated by circulating cues of nutritional state, including the adiposity hormones leptin …
Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons
Y Qi, NJ Lee, CK Ip, R Enriquez, R Tasan, L Zhang… - Cell Metabolism, 2023 - cell.com
… in AGRP neurons may be somewhat compensated for by increased Agrp expression under
negative energy balance. … of NPY neurons in the ARC that do not co-express Agrp and that …
negative energy balance. … of NPY neurons in the ARC that do not co-express Agrp and that …
[HTML][HTML] Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons–Implications for energy balance and glucose control
… neurons is also essential for proper energy balance [26], [27], [28], [29]. Moreover, GLP-1
receptors in POMC neurons … arcuate POMC and NPY/AgRP neuronal activity and contribute to …
receptors in POMC neurons … arcuate POMC and NPY/AgRP neuronal activity and contribute to …
[HTML][HTML] PGC-1α expression in murine AgRP neurons regulates food intake and energy balance
JF Gill, J Delezie, G Santos, C Handschin - Molecular metabolism, 2016 - Elsevier
… of various signaling pathways in AgRP neurons and thereby sheds additional light on the
regulation of whole body energy balance by hypothalamic neurons, which are attractive targets …
regulation of whole body energy balance by hypothalamic neurons, which are attractive targets …
Regulation of substrate utilization and adiposity by Agrp neurons
JP Cavalcanti-de-Albuquerque, J Bober… - Nature …, 2019 - nature.com
… contribution of Agrp neurons to adiposity and weight gain during obesogenic conditions,
we set out to selectively activate Agrp neurons under controlled positive energy balance. We …
we set out to selectively activate Agrp neurons under controlled positive energy balance. We …
POMC neuronal heterogeneity in energy balance and beyond: an integrated view
C Quarta, M Claret, LM Zeltser, KW Williams… - Nature …, 2021 - nature.com
… A second neuronal population co-expressing neuropeptide Y (… (AgRP) is instead activated
by negative energy balance. Following activation, NPY/AgRP neurons inhibit POMC neurons 5…
by negative energy balance. Following activation, NPY/AgRP neurons inhibit POMC neurons 5…
[HTML][HTML] Insulin controls food intake and energy balance via NPY neurons
… In light of our results, the lack of effects in AgRP neuron-specific … AgRP neurons are 100%
NPY co-expressing. However, this notion that most, if not all, ARC NPY neurons are also AgRP …
NPY co-expressing. However, this notion that most, if not all, ARC NPY neurons are also AgRP …
Control of energy expenditure by AgRP neurons of the arcuate nucleus: neurocircuitry, signaling pathways, and angiotensin
… to energy balance [5•]. In addition to neuropeptides AgRP and NPY, AgRP neurons also
release … Mice with specific deletion of the vesicular GABA transporter (Vgat) in AgRP neurons …
release … Mice with specific deletion of the vesicular GABA transporter (Vgat) in AgRP neurons …
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