Estrogen receptor beta as target for colorectal cancer prevention
… estrogen receptor beta (ERβ/ESR2) demonstrates an inverse relationship with the presence
of colorectal … of colorectal adenomatous polyps and prevention of colorectal carcinoma in …
of colorectal … of colorectal adenomatous polyps and prevention of colorectal carcinoma in …
Targeting estrogen receptors in colorectal cancer
JW Maingi, S Tang, S Liu, W Ngenya, E Bao - Molecular Biology Reports, 2020 - Springer
… Abnormal estrogen receptor signaling may increase the risk of development of a variety of
diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant …
diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant …
[HTML][HTML] Estrogen receptors in colorectal cancer: Facts, novelties and perspectives
I Ditonno, G Losurdo, M Rendina, M Pricci, B Girardi… - Current …, 2021 - mdpi.com
… role for estrogens has been hypothesized. Indeed, two isoforms of nuclear estrogen receptors
(ER) … While the binding of 17beta-estradiol to ERα activates anti-apoptotic pathways, the …
(ER) … While the binding of 17beta-estradiol to ERα activates anti-apoptotic pathways, the …
Colitis‐induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity
A Ibrahim, LW Hugerth, L Hases… - … journal of cancer, 2019 - Wiley Online Library
… Chronic inflammation of the colon is a risk factor for colorectal cancer (CRC). Hormone-replacement
therapy reduces CRC incidence, and the estrogen receptor beta (ERβ/ESR2) has …
therapy reduces CRC incidence, and the estrogen receptor beta (ERβ/ESR2) has …
[HTML][HTML] Significance of G protein-coupled estrogen receptor in the pathophysiology of irritable bowel syndrome, inflammatory bowel diseases and colorectal cancer
D Jacenik, WM Krajewska - Frontiers in Endocrinology, 2020 - frontiersin.org
… colitis as well as colorectal cancer. The G protein-coupled estrogen receptor appears to be
a … , proliferation and migration potential of colorectal cancer cells and seems to be a useful …
a … , proliferation and migration potential of colorectal cancer cells and seems to be a useful …
[HTML][HTML] Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis
AA Rawłuszko-Wieczorek, Ł Marczak, N Horst… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Dysregulation of estrogen related pathways is implicated colorectal cancer (CRC) … of estrone
(E1) and 17β-estradiol (E2) in relation to estrogen receptor (ESR) expression level was not …
(E1) and 17β-estradiol (E2) in relation to estrogen receptor (ESR) expression level was not …
Estrogen receptor β as a prognostic marker of tumor progression in colorectal cancer with familial adenomatous polyposis and sporadic polyps
PR Stevanato Filho, S Aguiar Junior… - Pathology & Oncology …, 2018 - Springer
… We studied 120 AC Camargo Cancer Center patients diagnosed with either FAP-associated …
levels of estrogen receptor (ER)-α, ER-β and the progesterone and androgen receptors (…
levels of estrogen receptor (ER)-α, ER-β and the progesterone and androgen receptors (…
Implications of estrogen and its receptors in colorectal carcinoma
… colorectal cancer (CRC) genesis. The functionality of estrogens in cancer is mediated by the
nuclear estrogen … In this review, we discuss the roles of estrogen receptors and their multiple …
nuclear estrogen … In this review, we discuss the roles of estrogen receptors and their multiple …
[HTML][HTML] Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer
Q Liu, Z Chen, G Jiang, Y Zhou, X Yang, H Huang… - Molecular cancer, 2017 - Springer
… Estrogenic signals are suggested to have protection roles in the development of colorectal
cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been reported to …
cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been reported to …
[HTML][HTML] Estrogen receptor β affects hypoxia response in colorectal cancer cells
AA Rawłuszko-Wieczorek, J Lipowicz… - … et Biophysica Acta (BBA …, 2024 - Elsevier
… In summary, estrogen receptor β has recently received more interest as a promising targeted
therapy for colorectal cancer, as it affects multiple pathways and the expression of a wide …
therapy for colorectal cancer, as it affects multiple pathways and the expression of a wide …
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