Estrogen receptors in colorectal cancer: Facts, novelties and perspectives

I Ditonno, G Losurdo, M Rendina, M Pricci, B Girardi… - Current …, 2021 - mdpi.com
… by treating HCT116 colon cancer cells with ERβ gene constructed into adenoviral vectors
alone or in combination with raloxifene, a selective estrogen receptor modulator. Only the …

Targeting estrogen receptors in colorectal cancer

JW Maingi, S Tang, S Liu, W Ngenya, E Bao - Molecular Biology Reports, 2020 - Springer
… Abnormal estrogen receptor signaling may increase the risk of development of a variety
of … Estrogen receptor beta (ERβ) is the predominant subtype in the colonic epithelium and …

Estrogen receptor beta as target for colorectal cancer prevention

C Williams, A DiLeo, Y Niv, JÅ Gustafsson - Cancer letters, 2016 - Elsevier
… Overexpression of PROX1 has been shown to enhance colon cancer progression in vivo;
indeed, it has been associated with transition from benign adenoma to carcinoma, and …

Estrogen receptor alpha regulates the Wnt/β-catenin signaling pathway in colon cancer by targeting the NOD-like receptors

S Liu, W Fan, X Gao, K Huang, C Ding, G Ma, L Yan… - Cellular signalling, 2019 - Elsevier
… in colon carcinoma cell by inhibited NLRP3 expression. In short, the research
demonstrates that NLRs are potential biomarkers for cancer, and ERs can regulate the Wnt/β-catenin …

Estrogen concentration and estrogen receptor-β expression in postmenopausal colon cancer considering patient/tumor background

N Honma, T Arai, Y Matsuda, Y Fukunaga… - Journal of Cancer …, 2022 - Springer
… Representative estrogen receptor (ER)-β staining of cancerous … a A mucinous carcinoma of
the cecum in a 78 years/o … important estrogen receptor, G protein-coupled estrogen receptor (…

[HTML][HTML] Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis

AA Rawłuszko-Wieczorek, Ł Marczak, N Horst… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Following, estrogen receptors mRNA level and estrogen concentration was inversely
correlated with CTNNB1 transcript levels whereas only estrogen receptors were negatively …

Estrogen receptor β as a prognostic marker of tumor progression in colorectal cancer with familial adenomatous polyposis and sporadic polyps

PR Stevanato Filho, S Aguiar Junior… - Pathology & Oncology …, 2018 - Springer
… and androgen receptors in FAP-associated and sporadic polyps and invasive carcinomas. …
expression of these hormone receptors and adenoma-carcinoma progression, CRC clinical …

[HTML][HTML] G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

D Jacenik, EJ Beswick, WM Krajewska… - World Journal of …, 2019 - ncbi.nlm.nih.gov
… α and β, as well as the membrane-bound G protein-coupled estrogen receptor (GPER). The
… GPER in the colon have shown that this estrogen receptor regulates colonic motility as well …

The roles of estrogen and estrogen receptors in gastrointestinal disease

C Chen, X Gong, X Yang, X Shang… - Oncology …, 2019 - spandidos-publications.com
Estrogen exhibits various functions through binding to its specific receptors, estrogen receptor
α, estrogen receptor … ERβ is encoded by estrogen receptor 2 or estrogen receptor 2, which …

Estradiol and progesterone regulate proliferation and apoptosis in colon cancer

CV Sasso, FE Santiano, FCV Arboccó… - Endocrine …, 2019 - ec.bioscientifica.com
… In addition, we observed a higher expression of estrogen receptor beta in these tumors. …
estrogen receptor beta in these tumors. We conclude that the action of both hormones, estradiol