Annual bleeding rates: pitfalls of clinical trial outcomes in hemophilia patients

C Keipert, M Müller‐Olling, F Gauly… - Clinical and …, 2020 - Wiley Online Library
estimation is prone to subjective assessment, as patients as … range of bleeding frequencies
among patients with similar … an efficacy measure in patients with hemophilia with and without …

Hemophilia prophylaxis adherence and bleeding using a tailored, frequency‐escalated approach: The Canadian Hemophilia Primary Prophylaxis Study

S Dover, VS Blanchette, D Wrathall… - … and Practice in …, 2020 - Wiley Online Library
… cohort of patients who enrolled in the study may have been more likely to be adherent to
their therapy than the general hemophilia population. For the CHPS, we excluded patients and …

The frequency of joint hemorrhages and procedures in nonsevere hemophilia A vs B

JM Soucie, PE Monahan, R Kulkarni… - Blood …, 2018 - ashpublications.org
… higher among hemophilia A than hemophilia B patients, and … The estimated value for this
risk factor was interpreted as the … are 0.09 fewer [because the estimate is a negative number] …

[HTML][HTML] … phenotype in nonsevere hemophilia by International Society on Thrombosis and Haemostasis bleeding assessment tool, bleeding frequency, and the joint …

J Rejtő, D Kraemmer, E Grilz, O Königsbrügge… - Research and Practice …, 2023 - Elsevier
… We estimatedhemophilia patients and detected arthropathy in 36.5%. Despite the different
methods to detect arthropathy, the rate was equal to the 36.6% of mild hemophilia patients

The frequency of complications in a cohort of patients diagnosed with hemophilia A and hemophilia B receiving prophylactic treatment in Colombia: A retrospective …

JE Machado Alba, JD Wilches-Gutierrez… - PLoS …, 2023 - journals.plos.org
… Sample size estimation was not performed due to the design of the study; therefore, all of …
in both the hemophilia A and hemophilia B patients. Table 3 shows the frequency of switches …

[HTML][HTML] Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

JA Abrantes, A Solms, D Garmann, EI Nielsen… - …, 2020 - ncbi.nlm.nih.gov
… to assess efficacy in hemophilia is bleeding frequency. This is … and bleeding patterns in
patients with severe hemophilia A, the … to estimate a bleeding hazard corresponding to untreated …

[PDF][PDF] Frequency of Hemophilia a and Severity of the Disease At Presentation

MA Shah - Northwest Journal of Medical Sciences, 2018 - researchgate.net
… %) hemophilia A patient among 545 patients with bleeding … of hemophilia in developing
world but it is estimated that 80% … This study was designed for the assessment of the frequency

What is the role for population pharmacokinetics in hemophilia?

A Iorio, A McEneny-King, A Keepanasseril… - International journal …, 2017 - Taylor & Francis
… preventing joint damage in hemophilia patients, as episodic … (ie, combination of dose and
frequency) and subsequently using … field of hemophilia, basic knowledge on PK estimates and …

Joint bleeding tendencies in adult patients with hemophilia: it's not all pharmacokinetics

JY Zhou, RFW Barnes, G Foster… - Clinical and Applied …, 2019 - journals.sagepub.com
frequencyestimates of half-life or Vd were taken from the respective pharmaceutical
companies’ drug inserts. We used patients’ infusion logs to build a simulation model to estimate

[HTML][HTML] Economic burden of illness among persons with hemophilia B from HUGS Vb: examining the association of severity and treatment regimens with costs and …

CX Chen, JR Baker, MB Nichol - Value in Health, 2017 - Elsevier
estimates for HA [14]. In addition, this study found generally low health care resource utilization
among patients … who have a higher bleeding frequency tend to use prophylactic treatment…