… gallium binding in vivo is the iron-transport protein transferrin; the ionic radii of Ga 3+ and Fe
3+ are similar, and Ga 3+ can bind to the iron-binding sites of transferrin… to transferrin during …

… transferrin (Tf) and is taken up by glioma cells via transferrin … that targeting the diverse
gallium-sensitive GBM cell … tumor vasculature by decreasing vessel diameter and permeability (62, …

… Iron is transported through the blood primarily as Fe(III) bound to transferrin (Tf), which is
taken into … Similarly, gallium, which binds both Tf sites about as strongly as Fe(III), did not have …

… transferrin to bind when a soluble gallium salt is administered orally or intravenously. Furthermore,
the deposition of insoluble gallium hydroxide Ga(OH)3 and insoluble gallium … gallium …

… Serum transferrin (sTf) is an 80 kDa glycoprotein that is part of the transferrin family of …
delivered to cells throughout the body via a transferrin receptor 1 (TfR) recognition pathway …

… by competing endogenous proteins, such as transferrin, and other ligands that compete for
Ga 3+ in vivo [4]. The iron transport protein transferrin is abundant in serum and its two metal …

… to transferrin, ferritin, and lactoferrin [7]. It stands to reason that gallium-68 would be as useful
as gallium-67 … Vascular permeability increases significantly to allow a significant influx of …

… be used to indicate any transferrin species containing iron and gallium, irrespective of metal
ion … is linked to increased blood flow and vascular permeability in these lesions and has not …

… vascular permeability as the predominant determinant of radiotracer accumulation.
Additional studies in CRPC patients harboring soft tissue metastases will be necessary to fully …

… the dissociation of more gallium from transferrin to restore the … compared to gallium-transferrin
drives the binding of gallium to … of gallium is probably linked to the increased permeability …