Ganciclovir therapeutic drug monitoring in transplant recipients

AG Märtson, AE Edwina, JGM Burgerhof… - Journal of …, 2021 - academic.oup.com
… exposure targets in ganciclovir therapy remains and to observe underexposure linked with
failure of therapy requires analysis of a wider patient population. Still, ganciclovir remains a …

Optimal use of ganciclovir and valganciclovir in transplanted patients: how does it relate to the outcome?

M Mozaffar, S Shahidi, M Mansourian… - … of Transplantation, 2018 - Wiley Online Library
… have serious consequences for patients. In this study, the outcome of transplant recipients
was assessed in relation to the optimal or suboptimal use of Ganciclovir or Valganciclovir. …

Systematic review of ganciclovir pharmacodynamics during the prevention of cytomegalovirus infection in adult solid organ transplant recipients

DD Wong, WJ van Zuylen, ME Craig… - Reviews in Medical …, 2019 - Wiley Online Library
… investigating the relationship between the therapeutic effect of different GCV blood … SOT
recipients, although given the low but significant numbers of transplant recipients failing therapy, …

Ganciclovir‐resistant cytomegalovirus infection in abdominal solid organ transplant recipients: case series and review of the literature

KE Rolling, MR Jorgenson… - … and Drug Therapy, 2017 - Wiley Online Library
treatment included four renal transplant recipients who did not have access to GCV.34 All
patients … a prospective study of LEF in 17 renal transplant recipients with mild CMV disease.35 …

Ganciclovir‐resistant cytomegalovirus infection in solid organ transplant recipients: a single‐center retrospective cohort study

PG Young, J Rubin, M Angarone… - Transplant Infectious …, 2016 - Wiley Online Library
… in lung transplant populations 12. In renal transplant recipients, the use of prophylactic
valGCV demonstrated less GCV resistance when compared to preemptive treatment (6.3% vs. …

Risk factors and outcomes of ganciclovir-resistant cytomegalovirus infection in solid organ transplant recipients

CE Fisher, JL Knudsen, ED Lease… - Clinical Infectious …, 2017 - academic.oup.com
patients approximately 1:3 to 109 adult transplant recipients who developed ganS-CMV
infection during the same time period. Patients … database of SOT recipients with CMV infection/…

Outcomes in transplant recipients treated with foscarnet for ganciclovir-resistant or refractory cytomegalovirus infection

RK Avery, R Arav-Boger, KA Marr, E Kraus… - …, 2016 - journals.lww.com
… of solid organ and hematopoietic stem cell transplant patients treated with foscarnet for …
Ganciclovir (GCV)-resistant or refractory cytomegalovirus (CMV) infection in transplant recipients

… from a randomized study of oral valganciclovir versus parenteral ganciclovir treatment of cytomegalovirus disease in solid organ transplant recipients: the VICTOR trial

A Åsberg, A Humar, H Rollag… - Clinical Infectious …, 2016 - academic.oup.com
… The VICTOR study showed comparable efficacy of treatment with intravenous ganciclovir
in solid organ transplant recipients. Oral therapy is now recommended treatment in clinical …

Optimization of Ganciclovir use in allogeneic hematopoietic cell transplant recipients–the role of therapeutic drug monitoring

SA Ho, M Slavin, JA Roberts, M Yong - … of Anti-infective Therapy, 2021 - Taylor & Francis
… The mainstay of treatment and prevention of this infection is ganciclovir and its ester prodrug
… of routine ganciclovir therapeutic drug monitoring (TDM) as a means to optimize treatment. …

Relationship of ganciclovir therapeutic drug monitoring with clinical efficacy and patient safety

BM Ritchie, JN Barreto, EF Barreto… - Antimicrobial agents …, 2019 - Am Soc Microbiol
… Our results were similar to a study in which 69 transplant patients utilized a standardized
ganciclovir dosing nomogram starting with 5 mg/kg every 12 h adjusted to renal function and …