Results from the phase III randomized trial of onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIB or IV non–small-cell lung cancer: METLung

DR Spigel, MJ Edelman, K O'Byrne… - Journal of Clinical …, 2017 - ascopubs.org
treated with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)
erlotinib, which improves patient outcomes in second-line therapy 9 and in first-line treatment for …

Gefitinib or erlotinib in previously treated non–small‐cell lung cancer patients: a cohort study in Taiwan

CH Chang, CH Lee, JC Ko, LY Chang… - Cancer …, 2017 - Wiley Online Library
… Among treatment modalities for lung cancer, the most promising therapy is the use of epidermal
growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Both erlotinib and gefitinib, …

Activity of erlotinib when dosed below the maximum tolerated dose for EGFR‐mutant lung cancer: Implications for targeted therapy development

BL Lampson, M Nishino, SE Dahlberg, D Paul… - Cancer, 2016 - Wiley Online Library
… The presence of an epidermal growth factor receptor (EGFR) mutation identifies a subset of
… In conclusion, we have observed that reduced-dose erlotinib for the treatment of patients with …

Comparison of afatinib and erlotinib combined with bevacizumab in untreated stage IIIB/IV epidermal growth factor receptor-mutated lung adenocarcinoma patients: a …

SH Lee, YC Lin, LC Chiu, JS Ju… - Therapeutic …, 2022 - journals.sagepub.com
erlotinib is a promising treatment for … growth factor (VEGF). A previous preclinical study
demonstrated that plasma VEGF and tumor VEGF mRNA levels increased after erlotinib treatment

[HTML][HTML] Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib

X Wang, K Chen, Y Yu, Y Xiang, JH Kim, W Gong… - Oncotarget, 2017 - ncbi.nlm.nih.gov
treatment options. Although targeted therapy, using tyrosine-kinase inhibitors such as erlotinib
… , only 15 % patients with mutated epidermal growth factor receptor (EGFR) in lung cancer …

KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene

MS Roberts, LJ Anstine, VS Finke, BL Bryson… - Breast Cancer …, 2020 - Springer
… not display amplification of the human epidermal growth factor receptor 2 (HER2) gene. …
treatment for TNBC. In 2019, atezolizumab, a PD-L1 inhibitor, was approved for the treatment of …

Epidermal growth factor receptor: Role in human cancer

P Rajaram, P Chandra, S Ticku, BK Pallavi… - Indian Journal of …, 2017 - journals.lww.com
… [ 21 ] Erlotinib is a FDA-approved therapy for the treatment of … Erlotinib prevention of oral
cancer study is the largest EGFR-… was to determine whether erlotinib can reduce oral cancer …

Substance P receptor blocker, aprepitant, inhibited cutaneous and other neurogenic inflammation side effects of the EGFR1-TKI, erlotinib

JJ Chmielinska, JH Kramer, IT Mak, CF Spurney… - Molecular and Cellular …, 2020 - Springer
treatment with the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI),
erlotinib. … impair the patient’s compliance with the treatment or even cause its discontinuation. In …

[HTML][HTML] … factor-1 expression in patients with non‑squamous non-small cell lung cancer with wild-type epidermal growth factor receptor treated with erlotinib

Y Nakahara, Y Hosomi, M Saito… - Molecular and …, 2016 - spandidos-publications.com
… of erlotinib treatment in patients expressing wild-type epidermal growth factor receptor (…
(NS‑NSCLC) and wild‑type EGFR who were treated with erlotinib alone as second- or later‑line …

… , randomized Phase 3 study of erlotinib (ERL) in combination with ramucirumab (RAM) or placebo (PL) in previously untreated patients with epidermal growth factor …

K Nakagawa, EB Garon, T Seto, M Nishio, S Ponce Aix… - 2019 - ascopubs.org
… Results: 449 pts were randomized characteristics were balanced between treatment arms:
Asian 77%, Females 63%, Ex19del 54%. RAM + ERL significantly prolonged PFS, DoR, and …