Hemophilia prophylaxis adherence and bleeding using a tailored, frequency‐escalated approach: The Canadian Hemophilia Primary Prophylaxis Study

S Dover, VS Blanchette, D Wrathall… - … and Practice in …, 2020 - Wiley Online Library
… of 56 boys with severe hemophilia A to tailored, frequency-escalated prophylaxis with an …
than the general hemophilia population. For the CHPS, we excluded patients and families …

Annual bleeding rates: pitfalls of clinical trial outcomes in hemophilia patients

C Keipert, M Müller‐Olling, F Gauly… - Clinical and …, 2020 - Wiley Online Library
… basic characteristics of the ABR endpoint. In addition, we analyzed study protocols from
contemporary hemophilia … to characterize differences in the methodology of ABR estimation. The …

The frequency of joint hemorrhages and procedures in nonsevere hemophilia A vs B

JM Soucie, PE Monahan, R Kulkarni… - Blood …, 2018 - ashpublications.org
… with hemophilia A to have undergone an orthopedic procedure… higher among hemophilia
A than hemophilia B patients, and … to prevent all joint bleeding in US males with hemophilia. …

[HTML][HTML] Performing and interpreting individual pharmacokinetic profiles in patients with Hemophilia A or B: Rationale and general considerations

A Iorio, AN Edginton, V Blanchette, J Blatny… - Research and practice …, 2018 - Elsevier
… In addition, utilization of a PopPK method to derive individual PK … with hemophilia. To
facilitate understanding this potential we will compare and contrast it to the traditional approach. …

Patient preferences for gene therapy in haemophilia: results from the PAVING threshold technique survey

E van Overbeeke, B Hauber, S Michelsen… - …, 2021 - Wiley Online Library
… While female haemophilia patients are very rare, 1% of our sample was female which is
in line with population estimations based on data provided by the patient organization (0%–1,97…

[HTML][HTML] Treatment options in hemophilia

W Miesbach, J Schwäble, MM Müller… - Deutsches Ärzteblatt …, 2019 - ncbi.nlm.nih.gov
hemophilia, and that 80 to 85% of these have hemophilia A (e1). In 2017 there were
approximately 4550 hemophilia patients … Various techniques are used to delay clearance, such as …

[PDF][PDF] Frequency of Hemophilia a and Severity of the Disease At Presentation

MA Shah - Northwest Journal of Medical Sciences, 2018 - researchgate.net
… management principles of hemophilia A patients as the severity of hemophilia A patients is
an important … Sampling technique was non probability consecutive sampling. A total of 245 …

Therapeutic and routine prophylactic properties of rFactor VIII Fc (efraloctocog alfa, Eloctate®) in hemophilia A

P Chowdary, E Fosbury, A Riddell… - Journal of blood …, 2016 - Taylor & Francis
… The use of EHL FVIII products in boys with severe hemophilia A will be an evolving process
… A pragmatic approach will be necessary to manage both clinician and patient expectations, …

Resonant acoustic rheometry to measure coagulation kinetics in hemophilia A and healthy plasma: a novel viscoelastic method

W Li, EC Hobson, CM Bunch, JB Miller… - … in thrombosis and …, 2023 - thieme-connect.com
Patients with hemophilia A pose challenging perioperative management because of the …
competence in patients with hemophilia A. However, the clinical manifestations of hemophilia A …

[HTML][HTML] Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

JA Abrantes, A Solms, D Garmann, EI Nielsen… - …, 2020 - ncbi.nlm.nih.gov
… exposure (factor VIII activity) and response (bleeding frequency) remains unclear. The aim
of … bleeding patterns and individual characteristics in severe hemophilia A patients. Pooled …