Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo

KJ Lavender, K Gibbert, KE Peterson, E Van Dis… - Journal of …, 2016 - Am Soc Microbiol
… of the IFN-α subtype that has the most potent anti-HIV-1 activity in vivo. These studies are
now necessary to assess the complex immunomodulatory effects of different IFN-α subtypes …

The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block

SJ Rihn, TL Foster, I Busnadiego, MA Aziz… - Journal of …, 2017 - Am Soc Microbiol
… our observations using HIV-1 NL4-3, the late IFN-γ-induced block to HIV-1 NHG replication
appeared to occur posttranscriptionally in MT4 cells as IFN-γ treatment inhibited transcription …

Increased expression of IL-32 correlates with IFN-γ, Th1 and Tc1 in virologically suppressed HIV-1-infected patients

…, C Nonne, O Turriziani, G Antonelli, G d'Ettorre… - Cytokine, 2019 - Elsevier
… that IL-32′s action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the … HIV-1
achieving viral suppression. To explore this hypothesis, transcript levels of IL-32 and IFN-γ

Type I interferon responses by HIV-1 infection: association with disease progression and control

…, Y Konno, K Yamamoto, Y Koyanagi… - Frontiers in …, 2018 - frontiersin.org
… -I responses triggered by HIV-1 infection are detrimental for … of infection, the role of IFN-Is
produced by HIV or SIV infection in … and minuses of HIV-1 infection stimulated IFN-I responses …

The effect of antiretroviral therapy on IL-6, IL-1β, TNF-α, IFN-γ levels and their relationship with HIV-RNA and CD4+ T cells in HIV patients

G Okay, MM Koc, EM Guler, A Yabaci… - Current HIV …, 2020 - ingentaconnect.com
IFN-γ levels were found to be high in asymptomatic carriers and patients receiving ART [5].
Unlike other cytokines, the course of IFN-γ levels in HIV… -α, and IFN-γ in HIV-infected patients …

[PDF][PDF] … of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1+ Mycobacterium Tuberculosis (Tb) Infected Patients/Interferona-gamma (Ifn-γ) …

I Januškevica, B Rozentāle, E Hagina… - Proceedings of the …, 2016 - sciendo.com
… : 1) the serum IFN-γ level was significantly higher in the HIV-1 patient group with primary TB,
2) patients with primary HIV-1/TB had higher IFN-γ levels and HIV-1 … higher in HIV-1 patients …

Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

…, CY Bahari, CM Shaw, Y Li… - Proceedings of the …, 2017 - National Acad Sciences
… ), and bioactive IFN levels are highly elevated during acute HIV-1 infection (37), we hypothesized
that IFN-mediated antiviral activity contributes to the HIV-1 transmission bottleneck. To …

A computational model of inhibition of HIV-1 by interferon-alpha

EP Browne, B Letham, C Rudin - PLoS One, 2016 - journals.plos.org
1 interferons such as interferon-alpha (IFNα) inhibit replication of Human immunodeficiency
virus (HIV-1… impacts spreading HIV-1 infection, we modeled the interaction of HIV-1 with CD4 …

[HTML][HTML] Impairment of the type I interferon response by HIV-1: potential targets for HIV eradication

TS Sandstrom, N Ranganath, JB Angel - Cytokine & Growth Factor Reviews, 2017 - Elsevier
… type I IFN response in primary cell models of HIV-1 infection. … (HIV-1) can circumvent host
antiviral signalling and establish persistent viral reservoirs. HIV-1-mediated defects in the IFN

Immune activation in the course of HIV1 infection: causes, phenotypes and persistence under therapy

M Younas, C Psomas, J Reynes, P Corbeau - HIV medicine, 2016 - Wiley Online Library
… The surviving NKT cells during HIV-1 infection have cell surface markers of exhaustion 75,
an impaired capacity to proliferate 75 and to produce interferon γ (IFNγ), as well as TNF-α …