New insights into the role of insulin and hypothalamic-pituitary-adrenal (HPA) Axis in the metabolic syndrome

JA Janssen - International journal of molecular sciences, 2022 - mdpi.com
… of the HPA axis plays an important etiological role in the development of the metabolic syndrome
and its … in preventing increased activation of the HPA axis and the metabolic syndrome. …

Neuroendocrinological and epigenetic mechanisms subserving autonomic imbalance and HPA dysfunction in the metabolic syndrome

E Lemche, OS Chaban, AV Lemche - Frontiers in Neuroscience, 2016 - frontiersin.org
… These lead to defects in the hypothalamic-pituitary-adrenal axis (HPA), which may progress
… Such associations between sympathetic hyperexcitability, HPA axis hyperactivation, and …

HPA axis dysregulation, NR3C1 polymorphisms and glucocorticoid receptor isoforms imbalance in metabolic syndrome

CS Martins, D Elias, LM Colli, CE Couri… - Diabetes/metabolism …, 2017 - Wiley Online Library
… sensitivity to GC feedback, confirming the HPA axis impairment in this condition. Our data
support the emerging concept that HPA axis disruption might be involved in the incompletely …

Recent advances in the role of cortisol and metabolic syndrome in age-related degenerative diseases

A Martocchia, M Stefanelli, GM Falaschi… - Aging clinical and …, 2016 - Springer
… The hippocampus exercises an important inhibitory control over the HPA axis (mediated by
γ-aminobutyric acid, GABA) and damage to this structure may stimulate the HPA axis itself [24…

Links between HPA axis and adipokines: clinical implications in paradigms of stress-related disorders

P Papargyri, E Zapanti, N Salakos… - … & Metabolism, 2018 - Taylor & Francis
… Low adiponectin concentrations have been associated with clinical components of the
metabolic syndrome including negative association with insulin resistance [Citation103], T2DM […

Hypothalamic-pituitary-adrenal (HPA) axis functioning in overtraining syndrome: findings from endocrine and metabolic responses on overtraining syndrome (EROS) …

FA Cadegiani, CE Kater - Sports Medicine-Open, 2017 - Springer
… not necessarily indicate impaired HPA axis function, but … and cardiovascular systems
to the HPA axis, rather than a … a complete evaluation of the HPA axis at different levels by …

[HTML][HTML] Functional hypercortisolism, visceral obesity and metabolic syndrome

L Min - Endocrine practice: official journal of the American …, 2016 - ncbi.nlm.nih.gov
… On one hand, the underweight state as occurs in patients with anorexia nervosa may
activate the HPA axis to increase adrenal cortisol production. The elevated cortisol level in the …

Hypothalamus-pituitary-adrenal Axis in Glucolipid metabolic disorders

Y Lin, Z Zhang, S Wang, J Cai, J Guo - … in Endocrine and Metabolic …, 2020 - Springer
… This review focuses on the role of HPA axis in GLMD and reviews the research … metabolic
syndrome [24]. FFAs are known to modulate the function of pituitary, implies that the HPA axis

Hair cortisol levels in posttraumatic stress disorder and metabolic syndrome

LL van den Heuvel, T Stalder, S du Plessis, S Suliman… - Stress, 2020 - Taylor & Francis
… The hypothalamicpituitaryadrenal (HPA) axis has therefore been a logical focus of
investigation into pathophysiological pathways involved in PTSD. Although HPA axis dysfunction …

Relative hypocortisolism is associated with obesity and the metabolic syndrome in recurrent affective disorders

M Maripuu, M Wikgren, P Karling, R Adolfsson… - Journal of Affective …, 2016 - Elsevier
… Before hypocortisolism has developed, HPA axis activity and cortisol levels can be expected
to fluctuate between normal and high, depending on the current state of the stress exposure…