[HTML][HTML] Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children
LFM Verscheijden, CHC Litjens… - PLoS Computational …, 2021 - journals.plos.org
… This study focused on the short-term analgesic effects after morphine administration, in which
morphine alone is mainly responsible for the analgesic effects. Accumulation of morphine-6…
morphine alone is mainly responsible for the analgesic effects. Accumulation of morphine-6…
[HTML][HTML] Brain reward circuits in morphine addiction
… related brain regions. Given the accumulated findings, a recent, emerging trend in morphine
… of neuronal interactions in brain reward circuits under the influence of morphine action. In …
… of neuronal interactions in brain reward circuits under the influence of morphine action. In …
The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites
MLF Martins, P Heydari, W Li… - Toxicology and Applied …, 2024 - Elsevier
… of the lack of mAbcb1 and mAbcg2 on morphine brain accumulation (around 8-fold higher
in … had no significant impact on the brain accumulation of morphine (Supplementary Fig. 3). …
in … had no significant impact on the brain accumulation of morphine (Supplementary Fig. 3). …
Cell-type specific differences in antiretroviral penetration and the effects of HIV-1 Tat and morphine among primary human brain endothelial cells, astrocytes, pericytes …
SH Patel, OA Ismaiel, WR Mylott Jr, M Yuan… - Neuroscience …, 2019 - Elsevier
… of antiretroviral drugs was greater in morphine-exposed HBMECs compared to other …
morphine exposure decreased drug accumulation. In summary, the intracellular accumulation of …
morphine exposure decreased drug accumulation. In summary, the intracellular accumulation of …
Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain
C Chaves, F Remiao, S Cisternino… - Current …, 2017 - ingentaconnect.com
… morphine and withdrawal from morphine did not alter brain-to… in terms of the brain accumulation
of radiolabeled sucrose, … /D3 human brain endothelial cell line to morphine were able to …
of radiolabeled sucrose, … /D3 human brain endothelial cell line to morphine were able to …
[HTML][HTML] Morphine accumulates in the retina following chronic systemic administration
N Bergum, CT Berezin, G Dooley, J Vigh - Pharmaceuticals, 2022 - mdpi.com
… levels seem to increase upon repeated systemic exposure, we wanted to compare the
deposition of morphine in the retina to the brain. We chose to compare the retina to the …
deposition of morphine in the retina to the brain. We chose to compare the retina to the …
[HTML][HTML] Morphine-element interactions–The influence of selected chemical elements on neural pathways associated with addiction
P Kupnicka, K Kojder, E Metryka, P Kapczuk… - Journal of Trace …, 2020 - Elsevier
… between morphine and zinc, manganese, chromium, cadmium, lead, fluoride, their impact
on neural pathways associated with addiction, and on antinociception and morphine tolerance …
on neural pathways associated with addiction, and on antinociception and morphine tolerance …
[HTML][HTML] Fluoride affects dopamine metabolism and causes changes in the expression of dopamine receptors (D1R and D2R) in chosen brain structures of morphine …
P Kupnicka, J Listos, M Tarnowski… - International Journal of …, 2020 - mdpi.com
… Accumulation of fluoride in the brain has been shown to cause neurodegenerative
changes in the striatum, motor cortex, cerebellum, and amygdala of rats [9,10]. Studies on the …
changes in the striatum, motor cortex, cerebellum, and amygdala of rats [9,10]. Studies on the …
[HTML][HTML] Morphine modulates doxorubicin uptake and improves efficacy of chemotherapy in an intracranial xenograft model of human glioblastoma
M da Ros, AL Iorio, D Consolante… - American Journal of …, 2016 - ncbi.nlm.nih.gov
… the role of morphine on the uptake of Dox by MDCKII cells transfected with human MDR1
gene … The data showed a Dox accumulation in MDCKII parental cells, without statistically …
gene … The data showed a Dox accumulation in MDCKII parental cells, without statistically …
Morphine-mediated brain region-specific astrocytosis involves the ER stress-autophagy axis
… brain tissue) [56]. Next, we sought to determine the optimal time of morphine-mediated induction
of GFAP expression in human … an increased accumulation of LC3-II/ p62 in human A172 …
of GFAP expression in human … an increased accumulation of LC3-II/ p62 in human A172 …