… Similarly, knockdown of the (P)RR in the SFO of human renin and angiotensinogen
double transgenic hypertensive mice significantly reduced blood pressure with concomitant …

… regulating hypertensive target organ damage through the generation of murine Agtr1a −/−
bone marrow chimeras. The Tsukuba mouse harbors the human renin and angiotensinogen …

… the memory of the renin phenotype and the intrinsic plasticity of renin cells to switch identity
to preserve homeostasis. Finally, we describe how permanent changes in renin cell fate lead …

… that, in the subfornical organ of the human brain, the (pro)renin receptor is expressed in …
renin receptor immunoreactivity in the subfornical organ is increased in hypertensive humans …

… The dysregulation of renin-angiotensin-system (RAS) plays a pivotal role in hypertension
and in the development of the related target organ damage (TOD). The main goal of treating …

… The image illustrates the main organs and components of the renin–angiotensin system.
Similarly, it illustrates the elements that make up the classic RAS and the alternative RAS, …

… Human studies suggest that excess aldosterone has a direct pro-inflammatory and fibrotic
effect, contributing to target organ degradation, which manifests itself in the development of …

… Here, we establish that pericytes are renin producing cells in the human kidney. Renin was
localized by immunohistochemistry in CD146 and NG2 expressing pericytes, surrounding …

… precursor of renin until the discovery the (pro)renin receptor [(P)RR] … In addition, binding of
renin and prorenin triggers … (pro)renin-(P)RR interaction could be a potential target for treating …

… -fold more human renin … human renin cDNA and the complete human renin amino acid
sequence. We then discovered the genomic sequences of human renin and its substrate, human …