Nitrative stress and tau accumulation in amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) in the Kii peninsula, Japan

Y Hata, N Ma, M Yoneda, S Morimoto… - Frontiers in …, 2018 - frontiersin.org
… Three control subjects showed positive staining for 8-NG and iNOS (60%), two controls …
AT-8, 8-NG, iNOS, NF-κB, and 8-OHdG in the patients with Kii ALS/PDC or AD was greater than …

Nitric oxide/nitric oxide synthase system in the pathogenesis of neurodegenerative disorders—an overview

OM Iova, GE Marin, I Lazar, I Stanescu, G Dogaru… - Antioxidants, 2023 - mdpi.com
… ’s disease, or amyotrophic lateral sclerosis. The mechanisms … The extensive prevalence of
nitrotyrosine immunoreactivity … of iNOS in transgenic AD mice or the use of iNOS inhibitors to …

Cyclo (His-Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells

S Grottelli, L Mezzasoma, P Scarpelli… - Molecular and Cellular …, 2019 - Elsevier
nitrotyrosine levels in hSOD1(G93A) microglial cells (Fig. 2A) and found a reduced nitrotyrosine
immunoreactivity … LPS-induced IL-6 and iNOS mRNA levels whereas the cyclic dipeptide …

Diphenyl diselenide protects motor neurons through inhibition of microglia-mediated inflammatory injury in amyotrophic lateral sclerosis

C Zhang, H Wang, W Liang, Y Yang, C Cong… - Pharmacological …, 2021 - Elsevier
… -2, inducible nitric oxide synthase (iNOS), and inhibitory molecules that block … nitrotyrosine
levels in primary hSOD1 G93A microglia and found a reduced nitrotyrosine immunoreactivity

An update on the role of nitric oxide in the neurodegenerative processes of Parkinson's disease

F Javier Jimenez-Jimenez… - Current medicinal …, 2016 - ingentaconnect.com
… and iNOS, suggesting the relation of mtNOS with nNOS [7]. … NOS1 shows no changes in
immunoreactivity in the striatum [66], … rodegeneration and formation of nitrotyrosine induced by …

Immunotherapies for movement disorders: Parkinson's disease and amyotrophic lateral sclerosis

C Schutt, HE Gendelman, RL Mosley - Neuroimmune Pharmacology, 2017 - Springer
… 22.2.4.2), large increases in gp91 phox immunoreactivity … and contributes to nitrotyrosine
formation on proteins such as α-… NF-kB, iNOS, nitro-tyrosine residues, phosphorylated p38, and …

Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons

CT Lee, LE Yu, JY Wang - Nitric oxide, 2016 - Elsevier
… using a commercial 3-Nitrotyrosine ELISA Kit. Further, the 3-… Furthermore, in patients with
amyotrophic lateral sclerosis, … formation, and 3-NT immunoreactivity in H 2 O 2 plus SNAP-…

Role and therapeutic potential of astrocytes in amyotrophic lateral sclerosis

M Pehar, BA Harlan, KM Killoy… - Current pharmaceutical …, 2017 - ingentaconnect.com
… Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords
of transgenic mice with a G93A mutant SOD1 gene. J Neuropathol Exp Neurol 2001; 60: 839…

Role of nitric oxide in neurodegeneration: function, regulation, and inhibition

D Tewari, AN Sah, S Bawari, SF Nabavi… - Current …, 2021 - ingentaconnect.com
… (AD), amyotrophic lateral sclerosis (ALS), Huntington’s … NOS involved in NO metabolism are
the iNOS, eNOS, and nNOS [… in the formation of 3-nitrotyrosine, due to the recombination of …

Endothelin-1 induces degeneration of cultured motor neurons through a mechanism mediated by nitric oxide and PI3K/Akt pathway

S D'Antoni, E Ranno, M Spatuzza, S Cavallaro… - Neurotoxicity …, 2017 - Springer
… the pathophysiology of amyotrophic lateral sclerosis (ALS). … at 4 C with anti-nitrotyrosine
antibody conjugated to magnetic … that both constitutive nNOS and iNOS are expressed in our …