Cancer immunotherapy by blocking immune checkpoints on innate lymphocytes

S Pesce, S Trabanelli, C Di Vito, M Greppi, V Obino… - Cancers, 2020 - mdpi.com
… successful cancer immunotherapy strategies … innate lymphocytes by ICI in both solid tumors
and hematological malignancies. Overall, we believe that, in our near future, immunotherapy

Immune checkpoints and innate lymphoid cells—new avenues for cancer immunotherapy

N Jacquelot, M Ghaedi, K Warner, DC Chung… - Cancers, 2021 - mdpi.com
… opportunities in cancer. Ideally innate lymphocyte responses would be modulated to work
in parallel with anti-tumor T cells to promote potent and long-lasting anti-tumor immunity. …

Exploring innate immunity in cancer immunotherapy: opportunities and challenges

X Li, H Dai, H Wang, W Han - Cellular & Molecular Immunology, 2021 - nature.com
… -based immunotherapies. Notably, myeloid cells and innate lymphocytes contribute to both
… Finally, selective context-specific targeting of the innate immune system has the potential to …

Innate immune signaling and regulation in cancer immunotherapy

L Corrales, V Matson, B Flood, S Spranger… - Cell research, 2017 - nature.com
cancer immunotherapies. The generation of a spontaneous T cell response against tumor-associated
antigens depends on innate … , suggesting that failed innate immune activation may …

Targeting innate immune pathways for cancer immunotherapy

LL Cao, JC Kagan - Immunity, 2023 - cell.com
… The innate immune system is critical for inducing durable and protective T cell responses to
… for cancer immunotherapy. In this review, we present a framework wherein distinct innate

[HTML][HTML] Helper-like innate lymphoid cells and cancer immunotherapy

A Crinier, E Vivier, M Blery - Seminars in Immunology, 2019 - Elsevier
… the emergence of cancer immunotherapy, a new kind of therapeutic strategy in which the
immune system is boosted, to enable it to kill tumor cells [5]. Immunotherapies may target the …

[HTML][HTML] The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy

AMK Law, E Lim, CJ Ormandy… - … -related cancer, 2017 - ncbi.nlm.nih.gov
… A critical concept underlying the current view of immunotherapy is that the ultimate end-effector
and therapeutic target of cancer immunotherapy is the tumour-specific T-cell. An …

Harnessing innate immunity in cancer therapy

O Demaria, S Cornen, M Daëron, Y Morel, R Medzhitov… - Nature, 2019 - nature.com
… to enhance the efficacy of both endogenous protective antitumour antibodies involved in
immunosurveillance and exogenous antitumour antibodies used in cancer immunotherapy. …

Promising targets for cancer immunotherapy: TLRs, RLRs, and STING-mediated innate immune pathways

K Li, S Qu, X Chen, Q Wu, M Shi - International journal of molecular …, 2017 - mdpi.com
… synergistic effects in cancer immunotherapy have been evidenced when innate and adaptive
innate and adaptive immune responses is necessary for efficient cancer immunotherapy. …

Innate lymphoid cells and cancer

N Jacquelot, C Seillet, E Vivier, GT Belz - Nature Immunology, 2022 - nature.com
… Despite the unprecedented success of this first wave of cancer immunotherapies based
on immune checkpoint inhibitors and CAR T cells, many people fail to benefit from such …