Short-term exposure to air pollution (PM2.5) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice

CM Campolim, L Weissmann, CKO Ferreira… - Scientific reports, 2020 - nature.com
… even worse, leading to leptin resistance, hyperphagia, and a … air pollution affects energy
homeostasis through the activation of hypothalamic inflammatory signaling and leptin resistance

Association between long-term exposure to air pollution and biomarkers related to insulin resistance, subclinical inflammation, and adipokines

K Wolf, A Popp, A Schneider, S Breitner, R Hampel… - Diabetes, 2016 - Am Diabetes Assoc
… Further associations were seen for leptin with all air pollutants (Table 5). Results in the
prediabetes subgroup may indicate some underlying systemic inflammatory processes. Our effect …

Fine particulate matter air pollution and aortic perivascular adipose tissue: Oxidative stress, leptin, and vascular dysfunction

P Haberzettl, L Jin, DW Riggs, J Zhao… - Physiological …, 2021 - Wiley Online Library
… Exposure to fine particulate matter (PM 2.5 ) air pollution … PVAT following short-term air
pollution exposure. Mice were … and aorta, upregulated PVAT leptin mRNA expression without …

Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study

W Li, KS Dorans, EH Wilker, MB Rice, I Kloog… - Environment …, 2018 - Elsevier
resistance (Kodavanti, 2015, Piya et al., 2013, Rajagopalan and Brook, 2012). Elevated air
pollution … lower levels of adiponectin and leptin than mice exposed to filtered air. A number of …

Air pollution accelerates the development of obesity and Alzheimer's disease: the role of leptin and inflammation-a mini-review

CM Campolim, BC Schimenes, MM Veras… - Frontiers in …, 2024 - frontiersin.org
… We examine evidence suggesting that immune system activation leads to leptin resistance,
a critical facet in these conditions. Additionally, we discuss the need for further research on …

Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress

P Haberzettl, TE O'Toole, A Bhatnagar… - Environmental health …, 2016 - ehp.niehs.nih.gov
… These findings reveal a novel link between pulmonary oxidative stress and vascular insulin
resistance—a link that may explain how air pollution increases the risk of developing both …

Associations of exposure to air pollution with insulin resistance: a systematic review and meta-analysis

J Dang, M Yang, X Zhang, H Ruan, G Qin, J Fu… - International journal of …, 2018 - mdpi.com
… This meta-analysis found no significant relationships between air pollutants and glucose,
HbA1c, and leptin. A number of studies have shown that long-term exposure to traffic …

[PDF][PDF] The impact of air pollution to obesity

S Simkova, M Veleminsky, RJ Sram - Neuroendocrinol. Lett., 2020 - nel.edu
… In this study air pollution by NOx exerted a stronger effect on BMI growth than traffic density.
… and ambient air pollution are associated with higher levels of cord blood leptin and HMW …

Maternal exposure to air pollution and umbilical asprosin concentration, a novel insulin-resistant marker

ZS Hosseini, H Heydari-Zarnagh, M Behmanesh… - Chemosphere, 2021 - Elsevier
… nearest major roads) and air pollution with umbilical asprosin … Our results suggested that
maternal exposure to air pollution … of the mechanisms whereby air pollutants impaired glucose …

Apolipoprotein E4, gender, body mass index, inflammation, insulin resistance, and air pollution interactions: Recipe for Alzheimer's disease development in Mexico …

L Calderón-Garcidueñas… - Journal of Alzheimer's …, 2017 - content.iospress.com
… Lavigne and coworkers [177] have a relevant paper showing strong associations between
air pollution variables and cord blood leptin levels adjusted for birth weight z-score. Their …