Lipotoxicity: impact on oocyte quality and reproductive efficiency in mammals
JPM Alves, M Bertolini, LR Bertolini… - Animal …, 2018 - animal-reproduction.org
… granulosa cells and cumulus-oocyte complexes (COCs), which leads to a decrease in …
regard to the effects of lipotoxicity on oocyte quality. Lipotoxicity and reproductive response …
regard to the effects of lipotoxicity on oocyte quality. Lipotoxicity and reproductive response …
Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells
WFA Marei, G Van Raemdonck, G Baggerman… - Scientific reports, 2019 - nature.com
… cellular responses to PA-induced lipotoxicity during in … lipotoxic effects to reduce the number
of fixed factors, increase statistical power and allow accurate interpretation of the complex …
of fixed factors, increase statistical power and allow accurate interpretation of the complex …
Cellular stress responses in oocytes: Molecular changes and clinical implications
WFA Marei, JLMR Leroy - … Biology and Translational Medicine, Volume 16 …, 2021 - Springer
… by which oocytes can sense and respond to stress are not … due to lipotoxicity, oxidative
stress, and heat stress on oocyte … mechanisms in whole cumulus-oocyte complexes (COCs) can …
stress, and heat stress on oocyte … mechanisms in whole cumulus-oocyte complexes (COCs) can …
Alpha-linolenic acid protects the developmental capacity of bovine cumulus–oocyte complexes matured under lipotoxic conditions in vitro
WFA Marei, J De Bie, O Mohey-Elsaeed… - Biology of …, 2017 - academic.oup.com
… -linolenic acid (ALA) during in vitro oocyte maturation (IVM) in the presence of … Bovine
cumulus–oocyte complexes (COCs) were … protected oocyte developmental capacity under …
cumulus–oocyte complexes (COCs) were … protected oocyte developmental capacity under …
Nonesterified fatty acid-induced endoplasmic reticulum stress in cattle cumulus oocyte complexes alters cell metabolism and developmental competence
… COCs is protective of potential damage to the oocyte caused by NEFAs [13, 14]; our data
reveals that the cumulus cells themselves are sensitive to lipotoxicity and respond accordingly. …
reveals that the cumulus cells themselves are sensitive to lipotoxicity and respond accordingly. …
[PDF][PDF] Mitochondria and lipid metabolism in mammalian oocytes and early embryos
J Bradley, K Swann - International Journal of Developmental Biology, 2019 - core.ac.uk
… (PDH) complex to acetyl CoA, which enters the citric acid (TCA) cycle of chemical … generation
of ATP often seen in lipotoxic stress. It is likely that this response is due to ER stress rather …
of ATP often seen in lipotoxic stress. It is likely that this response is due to ER stress rather …
Risks of using mitoquinone during in vitro maturation and its potential protective effects against lipotoxicity-induced oocyte mitochondrial stress
WFA Marei, O Mohey-Elsaeed, I Pintelon… - Journal of Assisted …, 2024 - Springer
… protein responses and redox regulation increase in these oocytes [18]. In this model, alteration
in … Collection of bovine cumulus oocyte complexes (COCs) from slaughterhouse ovaries …
in … Collection of bovine cumulus oocyte complexes (COCs) from slaughterhouse ovaries …
Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts …
KLJ Desmet, WFA Marei, C Richard… - Human …, 2020 - academic.oup.com
… SUMMARY ANSWER Surviving, morphologically normal blastocysts derived from bovine
oocytes that matured under lipotoxic conditions exhibit long-lasting cellular dysfunction at the …
oocytes that matured under lipotoxic conditions exhibit long-lasting cellular dysfunction at the …
166 Mitochondrial stress responses in bovine cumulus cells and oocytes matured under lipotoxic conditions: a proteomic insight
WFA Marei, G Van Raemdonck… - Reproduction …, 2019 - CSIRO Publishing
… (UPR) and protein translation may be different in oocytes than in somatic cells. … responses
in oocytes to those in cumulus cells (CC). We exposed bovine cumulus-oocyte complexes (…
in oocytes to those in cumulus cells (CC). We exposed bovine cumulus-oocyte complexes (…
Metabolic exchanges between the oocyte and its environment: focus on lipids
S Uzbekova, PS Bertevello… - Reproduction …, 2021 - CSIRO Publishing
… oocyte in phospholipids and cholesterol during maturation, and significant changes of FA
composition and related pathways in response to lipid modulators endorse the role of oocyte …
composition and related pathways in response to lipid modulators endorse the role of oocyte …
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