… granulosa cells and cumulus-oocyte complexes (COCs), which leads to a decrease in …
regard to the effects of lipotoxicity on oocyte quality. Lipotoxicity and reproductive response …

… cellular responses to PA-induced lipotoxicity during in … lipotoxic effects to reduce the number
of fixed factors, increase statistical power and allow accurate interpretation of the complex …

… by which oocytes can sense and respond to stress are not … due to lipotoxicity, oxidative
stress, and heat stress on oocyte … mechanisms in whole cumulus-oocyte complexes (COCs) can …

… -linolenic acid (ALA) during in vitro oocyte maturation (IVM) in the presence of … Bovine
cumulus–oocyte complexes (COCs) were … protected oocyte developmental capacity under …

… COCs is protective of potential damage to the oocyte caused by NEFAs [13, 14]; our data
reveals that the cumulus cells themselves are sensitive to lipotoxicity and respond accordingly. …

… (PDH) complex to acetyl CoA, which enters the citric acid (TCA) cycle of chemical … generation
of ATP often seen in lipotoxic stress. It is likely that this response is due to ER stress rather …

… protein responses and redox regulation increase in these oocytes [18]. In this model, alteration
in … Collection of bovine cumulus oocyte complexes (COCs) from slaughterhouse ovaries …

… SUMMARY ANSWER Surviving, morphologically normal blastocysts derived from bovine
oocytes that matured under lipotoxic conditions exhibit long-lasting cellular dysfunction at the …

… (UPR) and protein translation may be different in oocytes than in somatic cells. … responses
in oocytes to those in cumulus cells (CC). We exposed bovine cumulus-oocyte complexes (…

… oocyte in phospholipids and cholesterol during maturation, and significant changes of FA
composition and related pathways in response to lipid modulators endorse the role of oocyte …