Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates
DM Vargas, MA De Bastiani, ER Zimmer… - Alzheimer's Research & …, 2018 - Springer
… master regulator analyses on transcriptomic data of human hippocampus to identify transcription
factors (TFs) that can potentially act as master regulators … Master regulator analysis and …
factors (TFs) that can potentially act as master regulators … Master regulator analysis and …
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective
J Liu, SJ Clough, AJ Hutchinson… - Annual review of …, 2016 - annualreviews.org
… receptor antagonist luzindole (MT1/MT2-nonselective) and 4P-PDOT (MT2-selective) varies
… totally blind individuals who are unable to entrain their master body clock to the 24-h light-…
… totally blind individuals who are unable to entrain their master body clock to the 24-h light-…
Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes
W Yang, K Tang, Y Wang, Y Zhang, L Zan - Scientific Reports, 2017 - nature.com
… expression of adipogenic master regulator PPARγ; (B) the mRNA expression of adipogenic
master regulator C/EBPβ; (C) the mRNA expression of adipogenic master regulator C/EBPα; (…
master regulator C/EBPβ; (C) the mRNA expression of adipogenic master regulator C/EBPα; (…
[HTML][HTML] Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
A Tarocco, N Caroccia, G Morciano… - Cell death & …, 2019 - nature.com
… Here, we summarize molecular pathways in which melatonin is considered a master
regulator, with attention to cell death and inflammation mechanisms from basic, translational and …
regulator, with attention to cell death and inflammation mechanisms from basic, translational and …
Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep
… coupled melatonin MT 1 and MT 2 receptors has not yet been well-clarified. Recent
advancements using selective MT 1 / MT 2 receptor ligands and MT 1 /MT 2 receptor knockout mice …
advancements using selective MT 1 / MT 2 receptor ligands and MT 1 /MT 2 receptor knockout mice …
Osteopontin—a master regulator of epithelial-mesenchymal transition
AN Kothari, ML Arffa, V Chang, RH Blackwell… - Journal of clinical …, 2016 - mdpi.com
… OPN is positioned as an upstream and critical regulator of EMT (Figure 2A). … OPN and
many traditional “master regulators” provides evidence that OPN is a major regulator of EMT. …
many traditional “master regulators” provides evidence that OPN is a major regulator of EMT. …
Bcl-2 family proteins: master regulators of cell survival
J Hatok, P Racay - Biomolecular concepts, 2016 - degruyter.com
… , proteins of the Bcl-2 family play important roles in regulating other cellular pathways with a
… This review summarizes the recent knowledge about functions of Bcl-2 family proteins that …
… This review summarizes the recent knowledge about functions of Bcl-2 family proteins that …
The Mediator complex as a master regulator of transcription by RNA polymerase II
WF Richter, S Nayak, J Iwasa, DJ Taatjes - Nature Reviews Molecular …, 2022 - nature.com
… factors, distinct from those in the PIC, interact with elongating Pol II to control its function 2 .
… 1b and Supplementary Movie 2), in agreement with prior biochemical and cellular data 50,51,…
… 1b and Supplementary Movie 2), in agreement with prior biochemical and cellular data 50,51,…
The mechanism of melatonin and its receptor MT2 involved in the development of bovine granulosa cells
S Wang, W Liu, X Pang, S Dai, G Liu - International journal of molecular …, 2018 - mdpi.com
… melatonin and MT2 are essential regulator of bovine GCs function by modulating
reproduction-related genes expression, hormones secretion and other regulators of folliculogenesis. …
reproduction-related genes expression, hormones secretion and other regulators of folliculogenesis. …
Regulation of the master regulator FOXM1 in cancer
GB Liao, XZ Li, S Zeng, C Liu, SM Yang, L Yang… - Cell Communication and …, 2018 - Springer
FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor
that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the …
that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the …
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