[HTML][HTML] Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells
MA Cepeda, JJH Pelling, CL Evered, KC Williams… - Molecular cancer, 2016 - Springer
… Additionally, we analyzed the level of MT1-MMP protein in human 21 T breast cancer cell …
mammary carcinoma (IMC), to show that the metastatic cell line produces little MT1-MMP …
mammary carcinoma (IMC), to show that the metastatic cell line produces little MT1-MMP …
[HTML][HTML] The expanding role of MT1-MMP in cancer progression
AM Knapinska, GB Fields - Pharmaceuticals, 2019 - mdpi.com
… and regulators in HC1806 breast cancer cells [64]. … Thr567 phosphorylation increased
breast cancer cell type I … the MT1-MMP CT Thr567 enhances ovarian cancer aggregation (…
breast cancer cell type I … the MT1-MMP CT Thr567 enhances ovarian cancer aggregation (…
Cellular and molecular mechanisms of MT1-MMP-dependent cancer cell invasion
A Castro-Castro, V Marchesin… - Annual review of cell …, 2016 - annualreviews.org
… with MT1-MMP trafficking in molecular details is important for cancer cell biology and …
in situ–to–invasive transition of breast cancer (BC), it was recently reported that silencing of …
in situ–to–invasive transition of breast cancer (BC), it was recently reported that silencing of …
Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels
MA Cepeda, CL Evered, JJH Pelling… - Journal of cell …, 2017 - Springer
… , we demonstrated the identical inverse relationship between MMP-2 and -9 transcript and
… MT1-MMP positive breast cancer cells. To further analyze the relationship between MMP-2 …
… MT1-MMP positive breast cancer cells. To further analyze the relationship between MMP-2 …
… tethered matrix metalloproteinase MT1-MMP triggers an outside-in DNA damage response that impacts chemo-and radiotherapy responses of breast cancer
V Thakur, K Zhang, A Savadelis, P Zmina, B Aguila… - Cancer letters, 2019 - Elsevier
… by which triple negative breast cancer cells may better withstand genotoxic … matrix
metalloproteinase MT1-MMP. We show that inhibition of MT1-MMP is sufficient to sensitize cells to IR …
metalloproteinase MT1-MMP. We show that inhibition of MT1-MMP is sufficient to sensitize cells to IR …
[HTML][HTML] Radiation-induced lung metastasis development is MT1-MMP-dependent in a triple-negative breast cancer mouse model
G Bouchard, H Therriault, S Geha, R Bujold… - … Journal of Cancer, 2017 - nature.com
… triple-negative breast cancer (… treatment. In this study, an animal model of TNBC was used
to determine whether the expression of the cell membrane protease MT1-MMP in cancer cells …
to determine whether the expression of the cell membrane protease MT1-MMP in cancer cells …
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
C Lodillinsky, E Infante, A Guichard, R Chaligne… - Oncogene, 2016 - nature.com
… MT1-MMP levels in foci of invasive carcinoma cells we found in clinical samples of microinvasive
breast cancer… in response to cell adhesion signaling in DCIS.com tumor cells contacting …
breast cancer… in response to cell adhesion signaling in DCIS.com tumor cells contacting …
[HTML][HTML] TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
C Chevalier, G Collin, S Descamps… - Nature …, 2016 - nature.com
… in breast tumour cells by overexpressing TOM1L1 in the ERBB2- and TOM1L1-negative breast
cancer cell … (d) Western blot showing MT1-MMP expression in 12 breast cancer cell lines. …
cancer cell … (d) Western blot showing MT1-MMP expression in 12 breast cancer cell lines. …
[HTML][HTML] Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance
C Lodillinsky, L Fuhrmann, M Irondelle, O Pylypenko… - Oncogene, 2021 - nature.com
… components of breast tumor cells relative … MT1-MMP levels in the invasive components of
breast tumors, particularly in aggressive histological grade III and triple-negative breast cancers…
breast tumors, particularly in aggressive histological grade III and triple-negative breast cancers…
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function
A Castagnino, A Castro-Castro, M Irondelle… - Oncogene, 2018 - nature.com
… of breast cancer cells. We report that expression of coronin 1C is elevated in invasive human
breast cancers, correlates positively with MT1-MMP … prognostic factor in breast cancer. We …
breast cancers, correlates positively with MT1-MMP … prognostic factor in breast cancer. We …
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