… First, MT4-MMP is anchored to the membrane by a GPI anchor, a feature only shared with
MT6-MMP, and second, unlike most MT-MMPs, MT4-MMP is inefficient in the activation of pro-…

… However, we found MT4MMP protein to be abundantly … type that abundantly expresses the
MT4-MMP protein allowing us to study its synthesis and processing in an authentic cell type. …

… Our data indicate that MT4-MMP is internalized by the clathrin-independent carriers/GPI-…
other membrane-type MMP members. Although MT4-MMP localizes with caveolin-1, MT4-MMP …

… the control of the Mt4-mmp promoter [9] we have detailed that Mt4-mmp is expressed in …
Mt4-mmp expression is clearly related to vascular development. Our study reveals that Mt4-mmp …

… membrane-type subclass of the MMP family that includes four type I transmembrane MMPs
(MT1-MMP/MMP14, MT2-MMP/… membrane-associated MMPs (MT4-MMP/MMP17 and MT6-…

… ), and MMP24 (MT5-MMP), are anchored to the cell membrane … MMP17 (MT4-MMP) and
MMP25 (MT6-MMP) are instead … functions of type I TM and GPI-anchored MT-MMPs elaborately …

… MMP family are the membrane-type matrix metalloproteinases (MT-MMPs) that are anchored
to the cell membrane by a type I … type of anchoring to the cell membrane presented by MT4-…

… the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase. J Biol Chem
… the activity and turnover of membrane-type 1 matrix metalloproteinase. J Biol Chem 2002; …

… We aimed to determine the clinical relevance of membrane type-4 matrix metalloproteinase
(MT4-MMP), a membrane type matrix metalloproteinase that interacts with epidermal growth …

… of the membrane bound MT1-MMP in melanoma growth, invasion and metastasis. MT1-MMP
has … by either a glycosylphosphatidylinositol (GPI) anchor (MT4- and MT6-MMP) or a type I …