… direct transcriptional regulation of senescence-regulatory gene CDKN1A (p21 WAF1/CIP1
). … a negative or tumor-suppressing function in prostate cancer. We then generated stable …

… after p53 stabilization by Nutlin-3a treatment ( Fig. 4B ) (GSE77371). As a positive p53 target,
we analyzed the CDKN1A … p21 can function as a negative regulator of gene expression, …

… p53 is activated by increasing its stability and activity; however, under normal conditions, the
… and the cyclin-dependent kinase inhibitor 1A (CDKN1A)/p21 transcription start site; however…

… suppressor p21 in PPC1, HCT116, and p53-depleted HCT116 cells. Conversely, CDKN1A
… Our findings reveal that MAGE-A12 plays crucial roles in p21 stability and tumor growth, …

… In the generated network, CDKN1A that encodes for p21 appeared as a prominent node
and was chosen for further validation due to its relation to cancer progression (Fig. 1), another …

… prognosis; (2) the p53 negative regulator Mdm2 is frequently … for TP53 mutations and that
p53 protein stabilization predicts … of Mdm2, Mdm4 and p21/CDKN1A, consistent with a highly …

… p53 from being ubiquitinated, thus increasing its stability [31]. Considering that KLF12 might
act as a co-regulator of p53, … the protein stability of p53 by blocking the acetylation of p53. To …

… A549 cells with homozygous deletion of CDKN1A gene encoding p21 using CRISPR/Cas9, …
identification of a new axis regulating p21 stability is important for understanding how cells …

… kinase inhibitor 1A (CDKN1A), also known as p21 WAF1/CIP1 (p21), mediates p53-dependent
G 1 growth arrest [9], [10], [11], [12], [13], [14]. At high levels, p21 inhibits the function of …

… p21 is a novel negative regulator of p53 stability and therefore, may be used as a target to
restore p53 … , we propose that p21 reduces p53 stability by forming a complex with p53. The …