… We demonstrate that p53 controls CDC7 stability post-… The p53-dependent pathway of
CDC7 downregulation is … of p21 in CDC7 stability, we next treated isogenic HCT116 p21 …

… system to restore genome stability. Apoptosis is essential for … this process is CDKN1A, which
encodes the protein P21, which … Thus it is believed that P53 acts as a negative regulator of …

… As a positive control, the mRNA level of CDKN1A was increased… was critical in maintaining
the stability of EGFR 27 . We … As an indicator of p53 activation by Nutlin-3a, p21 was detected …

… , given the different mechanisms and interactors that lead to p53 stabilization and activation.
… -dependent kinase inhibitor p21 (CDKN1A) was the first transcriptional target of p53 to be …

… a stress response in which cells experience stable cell cycle arrest following stress-inducing …
ZBTB17 is a transcriptional negative regulator in the cell cycle (Fig. 2d). CDKN1A was also …

… to promote p53-dependent expression of the neighboring cell cycle gene, Cdkn1a/p21.
The … of nascent lincRNA-p21 transcripts, such as their length, stability, and PolII association. …

… Increasing evidence reveals that p21 Cip1/Waf1 is also … [8], and thus functions as a negative
regulator controlling cell cycle … irradiation, p21 Cip1/Waf1 regulates p53 stability, subcellular …

… of the downstream p53 target genes p21/CDKN1A and miR-… Consistent with its negative
regulation of senescence in normal … Here we presented evidence that despite stabilization and …

… A main mechanism governing p21 levels is through CDKN1A transcriptional activation by …
that regulates p21 stability through the mTORC1/4E-BP1 pathway and independently of p53, …

… to act as negative regulators of both CDKN1A/p21 and BBC3/… p53 regulatory genes operate
at the level of mRNA stability; … stability that are possible through measurement of CDKN1A/…