… stabilization of wildtype p53 delays the onset of ferroptosis in response to cystine deprivation.
This delay requires the p53 transcriptional target CDKN1A (encoding p21… the p53-p21 axis …

… of p53, the cyclin-dependent kinase inhibitor p21 (CDKN1A) … is the chief negative regulator
of p53 activity and stability 23. … that HMGA2 negatively regulated the stability of p53 protein …

… p53 stabilization by inhibiting the interaction with its negative … The CDKN1A gene codes
for the p21 WAF1 protein, a cyclin-… through the inhibition of p53 negative regulators and both …

… GAPDH served as a negative control for the p53 response, while p21 (CDKN1A) and PLK4
… leads to DNA damage and causes stabilization of p53, which triggers cell cycle arrest or …

… by inducing CDKN1A/p21 expression. In particular … in the complex regulation of genome
stability by p53. Telomere … chromosome ends, by sequestering its negative regulator miR-23a. In …

… and inhibits p53 downstream targets including p21, BAX, FAS… negative correlation between
DCAF13 and CDKN1A (p = 6.5… in the degradation and stabilization of p53 protein. To verify …

… Acetylation is of vital importance to regulation of p53. It increases the protein stability of p53,
… , as a cyclin-dependent kinase inhibitor, exert significant negative regulator of proliferation, …

… TP53 is mutated, p21 expression must be triggered by p53-… as a regulator of CDKN1A gene
expression in various p53-… -characterized protein, inhibited p21 gene and protein expression …

… and p53 are key players in maintaining genomic stability, but … of specific p53 downstream
factors such as CDKN1A (p21) … levels which are transcriptionally activated by p53. (6,8,9) In …

… negative regulator of tumor suppressor protein p53 29,… stabilization of the p53 protein
and subsequent transcriptional activation of primary p53 target genes such as MDM2, p21/CDKN1A…