[HTML][HTML] p38 MAPK inhibition: A promising therapeutic approach for COVID-19

JM Grimes, KV Grimes - Journal of molecular and cellular cardiology, 2020 - Elsevier
… damage by both directly upregulating p38 MAPK activity and downregulating a key p38
MAPK shut off mechanism by reducing ACE2 activity. Furthermore, p38 MAPK activation could …

[HTML][HTML] Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma

LJW Pua, CW Mai, FFL Chung, ASB Khoo… - International journal of …, 2022 - mdpi.com
p38 MAPK activities are found upregulated in nasopharyngeal carcinoma (NPC). Studies have
shown that activation of JNK and p38 MAPK … They regulate multiple transcription activities

[HTML][HTML] p38 MAPK signaling in osteoblast differentiation

E Rodríguez-Carballo, B Gámez… - Frontiers in cell and …, 2016 - frontiersin.org
… In this review, we will summarize the state of the art on p38 activity during … of p38 activity
and the key action of MAPK in bone development and homeostasis, we should consider p38 as …

[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction

C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
p38 MAPK cascade is activated either in response to the Aβ peptide or in the presence of
tauopathies. Here, we describe the role of p38 MAPK … ROS or p38 MAP kinase activity [69,70]. …

[HTML][HTML] p38 MAPK activity is associated with the histological degree of interstitial fibrosis in IgA nephropathy patients

J Lee, JN An, JH Hwang, H Lee, JP Lee, SG Kim - PLoS One, 2019 - journals.plos.org
p38 mitogen-activated protein kinase (MAPK) is associated with tissue fibrosis, and
inhibition of p38 MAPK … We aimed to investigate whether p38 MAPK activity in kidney tissue …

Mapping out p38 MAPK

EA Bonney - American Journal of Reproductive Immunology, 2017 - Wiley Online Library
p38 can arrest cell division by multiple pathways, including activation of p5347, and in the
so-called non classical pathway p38 can move to the nucleus itself and enhance the activity of …

[HTML][HTML] p38 MAPK pathway in the heart: new insights in health and disease

R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
p38 activity is regulated by phosphorylation at the end of a cascade composed of a MAPK
kinase (MKK) and an MKK kinase (MEKK) [11,12,13]. The cascade is initiated by one of …

[HTML][HTML] p38 signalling pathway

JJ Sanz-Ezquerro, A Cuenda - International Journal of Molecular …, 2021 - mdpi.com
… ) and with the downstream substrate MAPK activated protein kinase 2 (… p38MAPK in different
pathologies; and therapeutic opportunities associated with modulation of p38MAPK activity. …

ERK and p38 MAPK activities determine sensitivity to PI3K/mTOR inhibition via regulation of MYC and YAP

T Muranen, LM Selfors, J Hwang, LL Gallegos… - Cancer research, 2016 - AACR
… delineate how p38 activity is … p38 activity was significantly suppressed, as were markers of
DNA repair, suggesting that these cells have resolved the DNA damage stress leading to p38

[HTML][HTML] Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity

K Kanemaru, Y Nakamura, K Totoki… - Cell Death & …, 2017 - nature.com
… downregulation, p38 MAPK hyperactivation, … p38 mitogen-activated protein kinase (MAPK)
signaling. This study also reveals a possible link among PLCδ1 downregulation, p38 MAPK