… ; a pro-apoptotic tumor suppressor protein) has been shown to be associated with cisplatin
resistance in pancreatic cancer cells through upregulation of Akt/PI3K signaling [33]. PI3K/Akt/…

… have provided strong evidence on the role of PI3K/AKT/mTOR pathway in PDAC, clinical …
PI3K/AKT/mTOR pathway could provide valuable assets for treatment of pancreatic cancer …

… pancreatic cancer patients. In this review, we focus on PI3K/AKT/mTOR inhibitors that have
shown great anti-tumor potential in studies performed on xenograft models and pancreatic …

… Akt via … Akt phosphorylation and inhibits the transcription of PI3K, reducing its activation.
These results suggest that LAMB3 promotes tumor invasion via Akt activation through the PI3K …

… the PI3K-Akt signaling pathway and promotes pancreatic cancer growth in vivo To determine
whether IGF2BP2 promotes pancreatic cancer cell growth via the PI3K-Akt pathway in vivo …

… study provided the molecular mechanism of PI3K/Akt pathway and Plk1 in the pancreatic
cancer cell proliferation and apoptosis, which may benefit for the therapy of pancreatic cancer. …

… Uro A downregulated the oncogenic PI3K/AKT/mTOR signaling … tumor growth in both tumor
xenografts and genetically engineered mouse models in vivo by not only disrupting PI3K/AKT …

… increased PI3k/AKT… PI3K/Akt/mTOR cascade in human pancreatic cancer stem cells [35].
Accordingly, our results showed that autophagy was negatively regulated by the RAGE/PI3K/Akt…

… Thus, our results reveal that LY294002 displays the opposite effect on PI3K-dependent AKT
… -resistant pancreatic cancer cells. We suggest that targeting the PI3K/AKT signaling pathway …

… the proliferation, apoptosis and autophagy of human pancreatic cancer (PC) cell lines in vitro
… to establish an orthotopic pancreatic tumor model in nude mice. Tumor‑bearing nude mice …