Crosstalk between ROS and autophagy in tumorigenesis: understanding the multifaceted paradox

A Hasan, SF Rizvi, S Parveen, N Pathak, A Nazir… - Frontiers in …, 2022 - frontiersin.org
… Moreover, autophagy also plays a dual role, initially inhibiting tumor formation but … autophagy
and ROS where they can either suppress cancer formation or promote disease etiology. …

Dual role of autophagy in hallmarks of cancer

SS Singh, S Vats, AYQ Chia, TZ Tan, S Deng, MS Ong… - Oncogene, 2018 - nature.com
autophagy, mechanism of autophagy, as well as the paradoxical role of autophagy in cancer.
… elaborate on how autophagy plays a role in several hallmarks of cancer, and emergence of …

Telomeres and cancer: resolving the paradox

J Nassour, TT Schmidt… - Annual review of cancer …, 2021 - annualreviews.org
… This review focuses on the current knowledge of the dual role of telomeres in cancer and …
etiology. … It is worthy to note, however, that the role of autophagy in cancer is dynamic and …

The roles, controversies, and combination therapies of autophagy in lung cancer

Z Wang, C Zhou, S Yang - Cell Biology International, 2022 - Wiley Online Library
… exact function of autophagy in lung cancer are contradictory, … on lung cancer is that targeting
autophagy combined with … paradoxical reports about the exact function of autophagy in …

Therapeutic modulation of autophagy: which disease comes first?

MC Maiuri, G Kroemer - Cell Death & Differentiation, 2019 - nature.com
… On a pessimistic note, it is possible that close-to-etiological treatments like autophagy
induction would be administered at a stage that is too late to arrest—let alone, to revert—the …

[HTML][HTML] Aging, metabolism, and cancer development: from Peto's paradox to the Warburg effect

TR Tidwell, K Søreide, HR Hagland - Aging and disease, 2017 - ncbi.nlm.nih.gov
… Therefore, understanding its etiology and … autophagic machinery; furthermore, reduced
autophagic activity is associated with aging while evidence suggests that enhanced autophagy

Autophagy at the intersection of aging, senescence, and cancer

LD Cassidy, M Narita - Molecular Oncology, 2022 - Wiley Online Library
paradoxical result is due to the alleviation of age-associated dysfunctional autophagy which
… way that mirrors the etiology of human disease with regards to autophagic activity and aging…

Autophagy modulation in cancer: current knowledge on action and therapy

M Marinković, M Šprung, M Buljubašić… - … medicine and cellular …, 2018 - Wiley Online Library
… A complex multifactorial etiology of CRC is known, and, in recent years, autophagy has
been … Despite the seemingly paradoxical and dual role of autophagy in the context of tumor …

Autophagy: A boon or bane in oral cancer

N Adhauliya, AN Kalappanavar, IM Ali, RG Annigeri - Oral oncology, 2016 - Elsevier
… such as melanoma and backs the notion of an autophagy paradox [27]. … Hence it can
be assumed that Porphyromonas gingivalis, a major etiologic micro-organism of chronic …

… on implications of autophagy and apoptosis in tumorigenesis: possible alterations in autophagy through engineered nanomaterials and their importance in cancer …

H Ghaznavi, M Shirvaliloo, A Zarebkohan… - Molecular …, 2021 - ASPET
… In this review, we will discuss the signaling pathways involved in autophagy and the …
autophagy through engineered nanomaterials and their potential therapeutic applications in cancer. …