… caspase-1 activation (27, 28, 30). On the basis of our current findings, we propose that pathogen
blockade of TAK1-IKK triggers a caspase-8… Our observations suggest that the blockade …

… Host cells recognize blockade of caspase‐8‐mediated apoptosis by bacterial pathogens,
and trigger necroptosis as a backup defence strategy. Shigella flexneri counteracts this by type…

… Successful pathogens have therefore evolved ways to evade host … pathogen-associated
molecular patterns that cannot be recognized by macrophage TLRs or via active blockade of …

… (C) The BMDCs obtained from WT or Casp1/11−/− mice were primed with Pam3CSK4
and under caspase-8 activity blockade were incubated for 24 hours with P brasiliensis at a …

… as a safeguard to pathogenic inhibition of caspase-8. Overall, increasing amounts of
evidence point to caspase-8 as a molecule able to direct cells toward different types of death. …

… Cell death plays an important role during pathogen … and caspase-8 enzymatic activity,
which trigger the mitochondrial apoptotic effectors, BAX and BAK. The pro-apoptotic caspase-8 …

… of caspase-8 to cytokine production in response to bacterial infection and individual pathogen-…
As RIPK3-deficient cells do not undergo cell death in response to blockade of caspase …

… Mice with T reg -specific loss of Caspase-8 that survived the exaggerated inflammatory …
pathogens that are not normally cleared in wild-type (WT) mice. The rapid attrition of caspase-8–…

… caspase-8-dependent apoptosis and caspase-independent necroptotic cell death. TLR
signalling may therefore contribute to the pathogenic … are rescued by blockade of necroptotic …

… Indeed, blockade or evasion of apoptosis was listed as one of the original “hallmarks” of …
of caspase-8 may lie exactly here and it has to be kept in mind that pathogen recognition by …